Epigenetic Research in Stem Cell Bioengineering-Anti-Cancer Therapy, Regenerative and Reconstructive Medicine in Human Clinical Trials.

epigenome shows all the information related to the expression of genes that are not found in the DNA sequence but rather the result of a chemical change to histones and DNA. Epigenetic modifications act in a cooperative fashion to the regulation of gene expression, or transcription work at the post-transcriptional level, and plays a key role in determining the phenotypic variation in the cells containing the same genotype.

Epigenetic modifications important consideration in relation to anti-cancer therapy and regenerative / drug reconstruction. In addition, various clinical trials have been carried out, exploiting the potential of stem cell epigenetics in the engineering of applications in the treatment and diagnosis of disease. Epigenetic studies will likely become the basis of future cancer therapies, such as epigenetic modification plays a major role in tumor formation, malignancy and metastasis. In fact, a large number of current clinical approaches designed or tested, by compounds that regulate epigenetic pathways in a variety of tumor types, using this mechanism in stem cell biotechnology.


The aim of regenerative medicine repair the damage, tissue or organs for the treatment of various diseases, which have been less successful with conventional medications and medical procedures. Until now, the regenerative method multimodal including healthy organ transplantation, tissue, or cells, stimulation of the body to enable the healing response in damaged tissue, as well as the combined use of cells and bio-degradable scaffold to obtain a functional network. Of course, the stem cells are a promising tool in regenerative medicine due to their ability to induce the formation of tissue de novo and / or promote organ repair and regeneration.

Currently, several studies have shown that the effect of stem cells beneficial, especially for mesenchymal stem cells (MSC) and induced pluripotent stem cells (iPSCs) in the damaged tissue returns are not dependent on the engraftment and differentiation them at the injury site, but to their activities paracrine. It is now known that the paracrine actions of stem cells is their ability to release extracellular vesicles (EV). EVS plays an important role in cell to cell communication and are directly involved in tissue regeneration. In this review, we tried to summarize the molecular mechanism in which the MSC and iPSCs derived EVs perform their therapeutic action and their possible application for the treatment of several diseases.

 Epigenetic Research in Stem Cell Bioengineering-Anti-Cancer Therapy, Regenerative and Reconstructive Medicine in Human Clinical Trials.
Epigenetic Research in Stem Cell Bioengineering-Anti-Cancer Therapy, Regenerative and Reconstructive Medicine in Human Clinical Trials.

Regenerative Medicine for Spinal Cord Injury: Focus on Stem Cells and Biomaterials

Introduction: Spinal cord injury (SCI) is a medical pathology dramatic consequences of trauma (primary injury). However, the majority of post-trauma tissue degeneration caused by the so-called secondary injury, which is known as a multifactorial process. This, indeed, including a broad spectrum of events: the blood-brain barrier dysfunction, local inflammation, neuronal death, demyelination and nerve pathways termination.


Areas covered: Cell therapy is a promising drug targets for diseases and disorders at the cellular level, to restore the population of cells or the use of cells as therapeutic cargo carrier. In particular, regenerative medicine with stem cells is the most interesting category to use, thanks to their distinctive features.

Kinesin Antibody

GWB-A068EC 0.1 ml Ask for price

Kinesin Antibody

GWB-CFA5E7 0.1 mg Ask for price

Kinesin Antibody

abx140044-100g 100 µg
EUR 350

Kinesin 1 Antibody

39368-100ul 100ul
EUR 468

Kinesin 5A Antibody

DF13467 100ul
EUR 420

Kinesin 5A Antibody

DF13467-100ul 100ul
EUR 280

Kinesin 5A Antibody

DF13467-200ul 200ul
EUR 350

Kinesin 1 Antibody

E300631 100ug/200ul
EUR 275
Description: Available in various conjugation types.

Kinesin 5 C Antibody

DF13556 100ul
EUR 420

Kinesin 5 C Antibody

DF13556-100ul 100ul
EUR 280

Kinesin 5 C Antibody

DF13556-200ul 200ul
EUR 350

Kinesin light chain 1

AP84811 1mg
EUR 2640

Kinesin light chain 1

AP84889 1mg
EUR 2640

Kinesin 1 (KNS1) Antibody

abx430886-200ul 200 ul
EUR 460.8

Kinesin 1 (KNS1) Antibody

abx037626-100ug 100 ug
EUR 469.2

Kinesin 2 (KNS2) Antibody

20-abx129173
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Kinesin 2 (KNS2) Antibody

20-abx173259
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  • 1 mg
  • 200 ug

Kinesin 2 (KNS2) Antibody

20-abx225261
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  • 100 ul
  • 200 ul
  • 50 ul

Kinesin 1 (KNS1) Antibody

abx037626-1096tests 10 × 96 tests Ask for price

Kinesin 1 (KNS1) Antibody

abx037626-596tests 5 × 96 tests Ask for price

Kinesin 1 (KNS1) Antibody

abx037626-96tests 96 tests
EUR 337.5

Kinesin 1 (KNS1) Antibody

abx430886-200l 200 µl
EUR 387.5

Kinesin 1 Antibody (Biotin)

abx430869-200ul 200 ul
EUR 460.8

Kinesin 1 Antibody (Biotin)

abx430869-200l 200 µl
EUR 387.5

Recombinant Kinesin 2 (KNS2)

4-RPC554Hu01
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  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Kinesin 2 expressed in: E.coli

Kinesin Heavy Chain Antibody

abx411951-01mg 0.1 mg
EUR 844.8

Kinesin Heavy Chain Antibody

abx415744-01mg 0.1 mg
EUR 844.8

Kinesin (heavy chain) Antibody

abx140244-01mg 0.1 mg
EUR 510

Kinesin (heavy chain) Antibody

abx140245-01mg 0.1 mg
EUR 510

Kinesin Light Chain Antibody

GWB-6DFC97 0.1 mg Ask for price

Kinesin Heavy Chain Antibody

GWB-BD0D20 0.1 mg Ask for price

Kinesin (heavy chain) Antibody

abx140244-100g 100 µg
EUR 350

Kinesin (heavy chain) Antibody

abx140245-100g 100 µg
EUR 350

Kinesin light chain Antibody

abx345275-100g 100 µg Ask for price

Kinesin light chain Antibody

abx345275-20g 20 µg
EUR 250

Kinesin light chain Antibody

abx345275-50g 50 µg
EUR 350

Kinesin Heavy Chain Antibody

abx415744-200l 200 µl
EUR 650

Human Kinesin 2 ELISA Kit

IHUKNS2KT each
EUR 733
Description: Human Kinesin 2 ELISA Kit

Human Kinesin 2 (KNS2) Protein

20-abx166785
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Kinesin heavy chain isoform 5A

AP84211 1mg
EUR 2640

Kinesin heavy chain isoform 5A

AP84409 1mg
EUR 2640

Kinesin heavy chain isoform 5A

AP84548 1mg
EUR 2640

Kinesin light chain Antibody (HRP)

abx345276-100g 100 µg Ask for price

Kinesin light chain Antibody (HRP)

abx345276-20g 20 µg
EUR 250

Kinesin light chain Antibody (HRP)

abx345276-50g 50 µg
EUR 350

Kinesin-1 Heavy Chain (KIF5B) Antibody

abx234567-100ug 100 ug
EUR 577.2

Kinesin-1 Heavy Chain (KIF5B) Antibody

abx234567-100g 100 µg
EUR 350

Human Kinesin 2 (KNS2) CLIA Kit

20-abx493763
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  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

HTS Kinesin ATPase Endpoint Assay

BK053 KIT 1000 assays
EUR 988

Kinesin light chain Antibody (FITC)

abx345277-100g 100 µg Ask for price

Kinesin light chain Antibody (FITC)

abx345277-20g 20 µg
EUR 250

Kinesin light chain Antibody (FITC)

abx345277-50g 50 µg
EUR 350

Human Kinesin 2 (KNS2) ELISA Kit

DLR-KNS2-Hu 96T
EUR 463
Description: tissue homogenates or other biological fluids.

Human Kinesin 2 (KNS2) ELISA Kit

DLR-KNS2-Hu-48T 48T
EUR 620.4
Description: A sandwich quantitative ELISA assay kit for detection of Human Kinesin 2 (KNS2) in samples from tissue homogenates or other biological fluids.

Human Kinesin 2 (KNS2) ELISA Kit

DLR-KNS2-Hu-96T 96T
EUR 807.6
Description: A sandwich quantitative ELISA assay kit for detection of Human Kinesin 2 (KNS2) in samples from tissue homogenates or other biological fluids.

Human KNS2(Kinesin 2) ELISA Kit

ELK4057-48T 48T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human KNS2. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human KNS2. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human KNS2, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human KNS2 in the samples is then determined by comparing the OD of the samples to the standard curve.

Human KNS2(Kinesin 2) ELISA Kit

ELK4057-96T 96T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human KNS2. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human KNS2. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human KNS2, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human KNS2 in the samples is then determined by comparing the OD of the samples to the standard curve.

Human Kinesin 2 (KNS2) ELISA Kit

EKL58629-5x96T 5x96T
EUR 3793.35

Human Kinesin 2 (KNS2) ELISA Kit

EKL58629-96T 96T
EUR 798.6

Human Kinesin 2 (KNS2) ELISA Kit

DL-KNS2-Hu 96T
EUR 441
Description: tissue homogenates or other biological fluids.

Human Kinesin 2 (KNS2) ELISA Kit

EK15136 96Т
EUR 768

Human Kinesin 2 (KNS2) ELISA Kit

20-abx152130
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  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Kinesin 2 (KNS2) ELISA Kit

RD-KNS2-Hu-48T 48T
EUR 452.7
Description: tissue homogenates and other biological fluids.

Human Kinesin 2 (KNS2) ELISA Kit

RD-KNS2-Hu-48Tests 48 Tests
EUR 625.2

Human Kinesin 2 (KNS2) ELISA Kit

RD-KNS2-Hu-96T 96T
EUR 646.7
Description: tissue homogenates and other biological fluids.

Human Kinesin 2 (KNS2) ELISA Kit

RD-KNS2-Hu-96Tests 96 Tests
EUR 867.6

Human Kinesin 2 (KNS2) ELISA Kit

RDR-KNS2-Hu-48T 48T
EUR 475.34
Description: tissue homogenates and other biological fluids.

Human Kinesin 2 (KNS2) ELISA Kit

RDR-KNS2-Hu-48Tests 48 Tests
EUR 652.8

Human Kinesin 2 (KNS2) ELISA Kit

RDR-KNS2-Hu-96T 96T
EUR 679.04
Description: tissue homogenates and other biological fluids.

Human Kinesin 2 (KNS2) ELISA Kit

RDR-KNS2-Hu-96Tests 96 Tests
EUR 907.2

Human Kinesin 2(KNS2)ELISA Kit

QY-E01843 96T
EUR 433.2

Human Kinesin 2 (KNS2) ELISA Kit

SEC554Hu-10x96wellstestplate 10x96-wells test plate
EUR 5677.8
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Kinesin 2 (KNS2) in Tissue homogenates and other biological fluids.

Human Kinesin 2 (KNS2) ELISA Kit

SEC554Hu-1x48wellstestplate 1x48-wells test plate
EUR 572.76
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Kinesin 2 (KNS2) in Tissue homogenates and other biological fluids.

Human Kinesin 2 (KNS2) ELISA Kit

SEC554Hu-1x96wellstestplate 1x96-wells test plate
EUR 766.8
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Kinesin 2 (KNS2) in Tissue homogenates and other biological fluids.

Human Kinesin 2 (KNS2) ELISA Kit

SEC554Hu-5x96wellstestplate 5x96-wells test plate
EUR 3090.6
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Kinesin 2 (KNS2) in Tissue homogenates and other biological fluids.

Human Kinesin 2 (KNS2) ELISA Kit

4-SEC554Hu
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  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Kinesin 2 (KNS2) in samples from Tissue homogenates and other biological fluids. with no significant corss-reactivity with analogues from other species.

Kinesin light chain Antibody (Biotin)

abx345278-100g 100 µg Ask for price

Kinesin light chain Antibody (Biotin)

abx345278-20g 20 µg
EUR 250

Kinesin light chain Antibody (Biotin)

abx345278-50g 50 µg
EUR 350

Human Kinesin light chain 3 (KLC3)

1-CSB-YP012381HU
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  • 100ug
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  • 1MG
  • 200ug
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  • 50ug
Description: Recombinant Human Kinesin light chain 3(KLC3) expressed in Yeast

Human Kinesin light chain 3 (KLC3)

1-CSB-EP012381HU
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  • 100ug
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  • 1MG
  • 200ug
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  • 50ug
Description: Recombinant Human Kinesin light chain 3(KLC3) expressed in E.coli

KLC1 Antibody / Kinesin light chain 1

F54987-0.08ML 0.08 ml
EUR 140.25
Description: Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity.

KLC1 Antibody / Kinesin light chain 1

F54987-0.4ML 0.4 ml
EUR 330.65
Description: Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity.

Kinesin Light Chain 1 (KLC1) Antibody

20-abx321756
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  • 100 ul
  • 50 ul

Kinesin Light Chain 4 (KLC4) Antibody

20-abx304293
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Kinesin Light Chain 1 (KLC1) Antibody

20-abx214036
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  • 100 ul
  • 50 ul

Kinesin Light Chain 1 (KLC1) Antibody

20-abx214691
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  • 100 ul
  • 50 ul

Kinesin Light Chain 1 (KLC1) Antibody

abx234594-100ug 100 ug
EUR 610.8

Kinesin Light Chain 2 (KLC2) Antibody

abx234595-100ug 100 ug
EUR 610.8

Kinesin Light Chain 3 (KLC3) Antibody

abx234596-100ug 100 ug
EUR 610.8

Kinesin Light Chain 1 (KLC1) Antibody

20-abx113396
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  • 150 ul
  • 50 ul

Kinesin Light Chain 2 (KLC2) Antibody

20-abx113397
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  • 150 ul
  • 50 ul

Kinesin Light Chain 3 (KLC3) Antibody

20-abx113398
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  • 150 ul
  • 50 ul

Kinesin Light Chain 1 (KLC1) Antibody

abx146467-100ug 100 ug
EUR 469.2

Kinesin Light Chain 4 (KLC4) Antibody

abx145735-100ug 100 ug
EUR 469.2

Kinesin Light Chain 2 (KLC2) Antibody

abx145742-100ug 100 ug
EUR 469.2

Kinesin Light Chain 3 (KLC3) Antibody

abx145850-100ug 100 ug
EUR 469.2

Kinesin Light Chain 2 (KLC2) Antibody

20-abx003757
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  • 100 ul
  • 200 ul

Kinesin Light Chain 1 (KLC1) Antibody

20-abx004251
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  • 100 ul
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  • 20 ul
  • 50 ul

Kinesin Light Chain 2 (KLC2) Antibody

abx026678-400ul 400 ul
EUR 627.6

Kinesin Light Chain 2 (KLC2) Antibody

abx026678-80l 80 µl
EUR 343.2

Kinesin Light Chain 1 (KLC1) Antibody

abx034039-400ul 400 ul
EUR 627.6

Kinesin Light Chain 1 (KLC1) Antibody

abx034039-80l 80 µl
EUR 343.2

KLC1 Antibody / Kinesin light chain 1

RQ6566 100ug
EUR 356.15
Description: Kinesin light chain 1 is a protein that in humans is encoded by the KLC1 gene. Conventional kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports various cargos along microtubules toward their plus ends. The heavy chains provide the motor activity, while the light chains bind to various cargos. This gene encodes a member of the kinesin light chain family. It associates with kinesin heavy chain through an N-terminal domain, and six tetratricopeptide repeat (TPR) motifs are thought to be involved in binding of cargos such as vesicles, mitochondria, and the Golgi complex. Thus, kinesin light chains function as adapter molecules and not motors per se. Although previously named kinesin 2, this gene is not a member of the kinesin-2 / kinesin heavy chain subfamily of kinesin motor proteins. Extensive alternative splicing produces isoforms with different C-termini that are proposed to bind to different cargos; however, the full-length nature and/or biological validity of most of these variants have not been determined.

Kinesin light chain 1 Antibody / KLC1

RQ7365 100ug
EUR 419

Kinesin Light Chain 1 (KLC1) Antibody

abx004251-100l 100 µl
EUR 400

Kinesin Light Chain 1 (KLC1) Antibody

abx004251-20l 20 µl
EUR 175

Kinesin Light Chain 1 (KLC1) Antibody

abx004251-50l 50 µl
EUR 275

Kinesin Light Chain 4 (KLC4) Antibody

abx304293-100g 100 µg
EUR 362.5

Kinesin Light Chain 4 (KLC4) Antibody

abx304293-20g 20 µg
EUR 162.5

Kinesin Light Chain 4 (KLC4) Antibody

abx304293-50g 50 µg
EUR 250

Kinesin light chain 1 (KLC1) Antibody

abx129173-100l 100 µl
EUR 275

Kinesin light chain 1 (KLC1) Antibody

abx129173-1ml 1 ml
EUR 750

Kinesin light chain 1 (KLC1) Antibody

abx129173-200l 200 µl
EUR 337.5

Kinesin Light Chain 1 (KLC1) Antibody

abx113396-100l 100 µl
EUR 612.5

Kinesin Light Chain 2 (KLC2) Antibody

abx113397-100l 100 µl
EUR 612.5

Kinesin Light Chain 3 (KLC3) Antibody

abx113398-100l 100 µl
EUR 612.5

Kinesin Light Chain 4 (KLC4) Antibody

abx145735-1096tests 10 × 96 tests Ask for price

Kinesin Light Chain 4 (KLC4) Antibody

abx145735-596tests 5 × 96 tests Ask for price

Kinesin Light Chain 4 (KLC4) Antibody

abx145735-96tests 96 tests
EUR 337.5

Kinesin Light Chain 1 (KLC1) Antibody

abx034039-100g 100 µg
EUR 250

Kinesin Light Chain 1 (KLC1) Antibody

abx234594-100g 100 µg
EUR 350

Kinesin Light Chain 2 (KLC2) Antibody

abx234595-100g 100 µg
EUR 350

Kinesin Light Chain 3 (KLC3) Antibody

abx234596-100g 100 µg
EUR 350

Kinesin Light Chain 2 (KLC2) Antibody

abx145742-1096tests 10 × 96 tests Ask for price

Kinesin Light Chain 2 (KLC2) Antibody

abx145742-596tests 5 × 96 tests Ask for price

Kinesin Light Chain 2 (KLC2) Antibody

abx145742-96tests 96 tests
EUR 337.5

Kinesin Light Chain 3 (KLC3) Antibody

abx145850-1096tests 10 × 96 tests Ask for price

Kinesin Light Chain 3 (KLC3) Antibody

abx145850-596tests 5 × 96 tests Ask for price

Kinesin Light Chain 3 (KLC3) Antibody

abx145850-96tests 96 tests
EUR 337.5

Kinesin Light Chain 1 (KLC1) Antibody

abx146467-1096tests 10 × 96 tests Ask for price

Kinesin Light Chain 1 (KLC1) Antibody

abx146467-596tests 5 × 96 tests Ask for price

Kinesin Light Chain 1 (KLC1) Antibody

abx146467-96tests 96 tests
EUR 337.5

Kinesin Light Chain 2 (KLC2) Antibody

abx026678-400l 400 µl
EUR 518.75

Kinesin light chain 1 (KLC1) Antibody

abx173259-100l 100 µl
EUR 787.5

Kinesin light chain 1 (KLC1) Antibody

abx173259-1ml 1 ml Ask for price

Kinesin light chain 1 (KLC1) Antibody

abx173259-200l 200 µl Ask for price

Kinesin Light Chain 1 (KLC1) Antibody

abx214036-100l 100 µl
EUR 250

Kinesin Light Chain 1 (KLC1) Antibody

abx214691-100tests 100 tests
EUR 350

Kinesin Light Chain 1 (KLC1) Antibody

abx214691-200tests 200 tests Ask for price

Kinesin Light Chain 1 (KLC1) Antibody

abx214691-50tests 50 tests
EUR 250

Kinesin Light Chain 1 (KLC1) Antibody

abx321756-100g 100 µg
EUR 350

Kinesin Light Chain 1 (KLC1) Antibody

abx321756-50g 50 µg
EUR 250

Kinesin Heavy Chain Antibody (C-term)

GWB-C2281E 0.1 mg Ask for price

ELISA kit for Human KNS2 (Kinesin 2)

ELK4057 1 plate of 96 wells
EUR 518.4
Description: A sandwich ELISA kit for detection of Kinesin 2 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

expert opinion: Many preclinical research studies show that treatment of cells can enhance the function of sensory / motor animals and the show will be very promising for clinical trials. In particular, recent advances have led to development of biomaterials that aims to promote in situ cell delivery. This review dig into this topic discussed the possibility of cell treatment to increase the chances of medical in the repair of the SCI.