Epigenetic Research in Stem Cell Bioengineering-Anti-Cancer Therapy, Regenerative and Reconstructive Medicine in Human Clinical Trials.
»
Epigenetic Research in Stem Cell Bioengineering-Anti-Cancer Therapy, Regenerative and Reconstructive Medicine in Human Clinical Trials.
epigenome shows all the information related to the expression of genes that are not found in the DNA sequence but rather the result of a chemical change to histones and DNA. Epigenetic modifications act in a cooperative fashion to the regulation of gene expression, or transcription work at the post-transcriptional level, and plays a key role in determining the phenotypic variation in the cells containing the same genotype.
Epigenetic modifications important consideration in relation to anti-cancer therapy and regenerative / drug reconstruction. In addition, various clinical trials have been carried out, exploiting the potential of stem cell epigenetics in the engineering of applications in the treatment and diagnosis of disease. Epigenetic studies will likely become the basis of future cancer therapies, such as epigenetic modification plays a major role in tumor formation, malignancy and metastasis. In fact, a large number of current clinical approaches designed or tested, by compounds that regulate epigenetic pathways in a variety of tumor types, using this mechanism in stem cell biotechnology.
The aim of regenerative medicine repair the damage, tissue or organs for the treatment of various diseases, which have been less successful with conventional medications and medical procedures. Until now, the regenerative method multimodal including healthy organ transplantation, tissue, or cells, stimulation of the body to enable the healing response in damaged tissue, as well as the combined use of cells and bio-degradable scaffold to obtain a functional network. Of course, the stem cells are a promising tool in regenerative medicine due to their ability to induce the formation of tissue de novo and / or promote organ repair and regeneration.
Currently, several studies have shown that the effect of stem cells beneficial, especially for mesenchymal stem cells (MSC) and induced pluripotent stem cells (iPSCs) in the damaged tissue returns are not dependent on the engraftment and differentiation them at the injury site, but to their activities paracrine. It is now known that the paracrine actions of stem cells is their ability to release extracellular vesicles (EV). EVS plays an important role in cell to cell communication and are directly involved in tissue regeneration. In this review, we tried to summarize the molecular mechanism in which the MSC and iPSCs derived EVs perform their therapeutic action and their possible application for the treatment of several diseases.
Epigenetic Research in Stem Cell Bioengineering-Anti-Cancer Therapy, Regenerative and Reconstructive Medicine in Human Clinical Trials.
Regenerative Medicine for Spinal Cord Injury: Focus on Stem Cells and Biomaterials
Introduction: Spinal cord injury (SCI) is a medical pathology dramatic consequences of trauma (primary injury). However, the majority of post-trauma tissue degeneration caused by the so-called secondary injury, which is known as a multifactorial process. This, indeed, including a broad spectrum of events: the blood-brain barrier dysfunction, local inflammation, neuronal death, demyelination and nerve pathways termination.
Areas covered: Cell therapy is a promising drug targets for diseases and disorders at the cellular level, to restore the population of cells or the use of cells as therapeutic cargo carrier. In particular, regenerative medicine with stem cells is the most interesting category to use, thanks to their distinctive features.
Description: A sandwich quantitative ELISA assay kit for detection of Human Kinesin 2 (KNS2) in samples from tissue homogenates or other biological fluids.
Description: A sandwich quantitative ELISA assay kit for detection of Human Kinesin 2 (KNS2) in samples from tissue homogenates or other biological fluids.
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Kinesin 2 (KNS2) in Tissue homogenates and other biological fluids.
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Kinesin 2 (KNS2) in Tissue homogenates and other biological fluids.
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Kinesin 2 (KNS2) in Tissue homogenates and other biological fluids.
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Kinesin 2 (KNS2) in Tissue homogenates and other biological fluids.
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Kinesin 2 (KNS2) in samples from Tissue homogenates and other biological fluids. with no significant corss-reactivity with analogues from other species.
Description: Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity.
Description: Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity.
Description: Kinesin light chain 1 is a protein that in humans is encoded by the KLC1 gene. Conventional kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports various cargos along microtubules toward their plus ends. The heavy chains provide the motor activity, while the light chains bind to various cargos. This gene encodes a member of the kinesin light chain family. It associates with kinesin heavy chain through an N-terminal domain, and six tetratricopeptide repeat (TPR) motifs are thought to be involved in binding of cargos such as vesicles, mitochondria, and the Golgi complex. Thus, kinesin light chains function as adapter molecules and not motors per se. Although previously named kinesin 2, this gene is not a member of the kinesin-2 / kinesin heavy chain subfamily of kinesin motor proteins. Extensive alternative splicing produces isoforms with different C-termini that are proposed to bind to different cargos; however, the full-length nature and/or biological validity of most of these variants have not been determined.
Description: A sandwich ELISA kit for detection of Kinesin 2 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.
Description: A competitive ELISA for quantitative measurement of Canine Kinesin light chain 2 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Canine Kinesin light chain 2 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Canine Kinesin light chain 2 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Rat Kinesin light chain 2 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Rat Kinesin light chain 2 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Rat Kinesin light chain 2 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Porcine Kinesin light chain 2 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Porcine Kinesin light chain 2 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Porcine Kinesin light chain 2 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Goat Kinesin light chain 2 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Goat Kinesin light chain 2 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Goat Kinesin light chain 2 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Human Kinesin light chain 2 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Human Kinesin light chain 2 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Human Kinesin light chain 2 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Mouse Kinesin light chain 2 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Mouse Kinesin light chain 2 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Mouse Kinesin light chain 2 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
expert opinion: Many preclinical research studies show that treatment of cells can enhance the function of sensory / motor animals and the show will be very promising for clinical trials. In particular, recent advances have led to development of biomaterials that aims to promote in situ cell delivery. This review dig into this topic discussed the possibility of cell treatment to increase the chances of medical in the repair of the SCI.
