Epigenetic Research in Stem Cell Bioengineering-Anti-Cancer Therapy, Regenerative and Reconstructive Medicine in Human Clinical Trials.
epigenome shows all the information related to the expression of genes that are not found in the DNA sequence but rather the result of a chemical change to histones and DNA. Epigenetic modifications act in a cooperative fashion to the regulation of gene expression, or transcription work at the post-transcriptional level, and plays a key role in determining the phenotypic variation in the cells containing the same genotype.
Epigenetic modifications important consideration in relation to anti-cancer therapy and regenerative / drug reconstruction. In addition, various clinical trials have been carried out, exploiting the potential of stem cell epigenetics in the engineering of applications in the treatment and diagnosis of disease. Epigenetic studies will likely become the basis of future cancer therapies, such as epigenetic modification plays a major role in tumor formation, malignancy and metastasis. In fact, a large number of current clinical approaches designed or tested, by compounds that regulate epigenetic pathways in a variety of tumor types, using this mechanism in stem cell biotechnology.
The aim of regenerative medicine repair the damage, tissue or organs for the treatment of various diseases, which have been less successful with conventional medications and medical procedures. Until now, the regenerative method multimodal including healthy organ transplantation, tissue, or cells, stimulation of the body to enable the healing response in damaged tissue, as well as the combined use of cells and bio-degradable scaffold to obtain a functional network. Of course, the stem cells are a promising tool in regenerative medicine due to their ability to induce the formation of tissue de novo and / or promote organ repair and regeneration.
Currently, several studies have shown that the effect of stem cells beneficial, especially for mesenchymal stem cells (MSC) and induced pluripotent stem cells (iPSCs) in the damaged tissue returns are not dependent on the engraftment and differentiation them at the injury site, but to their activities paracrine. It is now known that the paracrine actions of stem cells is their ability to release extracellular vesicles (EV). EVS plays an important role in cell to cell communication and are directly involved in tissue regeneration. In this review, we tried to summarize the molecular mechanism in which the MSC and iPSCs derived EVs perform their therapeutic action and their possible application for the treatment of several diseases.

Regenerative Medicine for Spinal Cord Injury: Focus on Stem Cells and Biomaterials
Introduction: Spinal cord injury (SCI) is a medical pathology dramatic consequences of trauma (primary injury). However, the majority of post-trauma tissue degeneration caused by the so-called secondary injury, which is known as a multifactorial process. This, indeed, including a broad spectrum of events: the blood-brain barrier dysfunction, local inflammation, neuronal death, demyelination and nerve pathways termination.
Areas covered: Cell therapy is a promising drug targets for diseases and disorders at the cellular level, to restore the population of cells or the use of cells as therapeutic cargo carrier. In particular, regenerative medicine with stem cells is the most interesting category to use, thanks to their distinctive features.
Anti-Kinesin Purified |
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11-434-C100 | ExBio | 0.1 mg | EUR 244.8 |
Anti-Kinesin antibody |
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STJ16101149 | St John's Laboratory | 100 µg | EUR 628.8 |
anti-Kinesin C2 |
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YF-PA21681 | Abfrontier | 50 ul | EUR 435.6 |
Description: Mouse polyclonal to Kinesin C2 |
anti-Kinesin C2 |
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YF-PA21682 | Abfrontier | 50 ug | EUR 435.6 |
Description: Mouse polyclonal to Kinesin C2 |
Kinesin 5 C Antibody |
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DF13556 | Affbiotech | 100ul | EUR 420 |
Kinesin 2 (KNS2) Antibody |
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20-abx173259 | Abbexa |
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Kinesin (heavy chain) Antibody |
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abx140244-01mg | Abbexa | 0.1 mg | EUR 510 |
Kinesin (heavy chain) Antibody |
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abx140245-01mg | Abbexa | 0.1 mg | EUR 510 |
Kinesin 2 (KNS2) Antibody |
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20-abx129173 | Abbexa |
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Kinesin 1 (KNS1) Antibody |
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abx037626-100ug | Abbexa | 100 ug | EUR 469.2 |
Kinesin 2 (KNS2) Antibody |
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20-abx225261 | Abbexa |
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Kinesin Heavy Chain Antibody |
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abx415744-01mg | Abbexa | 0.1 mg | EUR 844.8 |
Kinesin 1 Antibody (Biotin) |
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abx430869-200ul | Abbexa | 200 ul | EUR 460.8 |
Kinesin 1 (KNS1) Antibody |
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abx430886-200ul | Abbexa | 200 ul | EUR 460.8 |
Kinesin Heavy Chain Antibody |
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abx411951-01mg | Abbexa | 0.1 mg | EUR 844.8 |
Recombinant Kinesin 2 (KNS2) |
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4-RPC554Hu01 | Cloud-Clone |
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Description: Recombinant Human Kinesin 2 expressed in: E.coli |
Anti-Kinesin Heavy Chain Purified |
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11-390-C025 | ExBio | 0.025 mg | EUR 146.4 |
Anti-Kinesin Heavy Chain Purified |
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11-390-C100 | ExBio | 0.1 mg | EUR 244.8 |
Anti-Kinesin Heavy Chain Purified |
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11-391-C025 | ExBio | 0.025 mg | EUR 146.4 |
Anti-Kinesin Heavy Chain Purified |
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11-391-C100 | ExBio | 0.1 mg | EUR 244.8 |
Human Kinesin 2 (KNS2) Protein |
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20-abx166785 | Abbexa |
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Anti-Kinesin 1 / UKHC antibody |
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STJ70199 | St John's Laboratory | 100 µg | EUR 430.8 |
Mouse Kinesin-like protein KIF1A (Kif1a) |
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1-CSB-EP012318MO | Cusabio |
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Description: Recombinant Mouse Kinesin-like protein KIF1A(Kif1a),partial expressed in E.coli |
Rat Kinesin-like protein KIF1C (Kif1c) |
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1-CSB-EP012320RA | Cusabio |
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Description: Recombinant Rat Kinesin-like protein KIF1C(Kif1c) expressed in E.coli |
Human Kinesin light chain 3 (KLC3) |
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1-CSB-EP012381HU | Cusabio |
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Description: Recombinant Human Kinesin light chain 3(KLC3) expressed in E.coli |
Rat Kinesin-like protein KIF1C (Kif1c) |
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1-CSB-YP012320RA | Cusabio |
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Description: Recombinant Rat Kinesin-like protein KIF1C(Kif1c) ,partial expressed in Yeast |
Human Kinesin light chain 3 (KLC3) |
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1-CSB-YP012381HU | Cusabio |
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Description: Recombinant Human Kinesin light chain 3(KLC3) expressed in Yeast |
Human Kinesin 2 (KNS2) ELISA Kit |
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DLR-KNS2-Hu-48T | DL Develop | 48T | EUR 620.4 |
Description: A sandwich quantitative ELISA assay kit for detection of Human Kinesin 2 (KNS2) in samples from tissue homogenates or other biological fluids. |
Human Kinesin 2 (KNS2) ELISA Kit |
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DLR-KNS2-Hu-96T | DL Develop | 96T | EUR 807.6 |
Description: A sandwich quantitative ELISA assay kit for detection of Human Kinesin 2 (KNS2) in samples from tissue homogenates or other biological fluids. |
Kinesin Family, Member 5A (KIF5A) Antibody |
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20-abx102657 | Abbexa |
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Kinesin Family, Member 5A (KIF5A) Antibody |
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20-abx102658 | Abbexa |
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Kinesin Family, Member 5A (KIF5A) Antibody |
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20-abx102659 | Abbexa |
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Kinesin Family Member 1C (KIF1C) Antibody |
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20-abx110446 | Abbexa |
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Kinesin Family Member 11 (KIF11) Antibody |
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abx159578-100ul | Abbexa | 100 ul | EUR 560.4 |
Kinesin Family Member 7 (KIF7) Antibody |
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20-abx159579 | Abbexa |
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Kinesin-Like Protein KIF23 (KIF23) Antibody |
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20-abx149303 | Abbexa |
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Chromosome-Associated Kinesin KIF4B (KIF4B) Antibody |
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20-abx149328 | Abbexa |
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Human Kinesin 2 (KNS2) ELISA Kit |
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20-abx152130 | Abbexa |
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Kinesin Family, Member 14 (KIF14) Antibody |
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20-abx173260 | Abbexa |
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Kinesin Family, Member 18A (KIF18A) Antibody |
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20-abx173261 | Abbexa |
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Kinesin Family, Member 1A (KIF1A) Antibody |
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20-abx173262 | Abbexa |
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Kinesin Family, Member 20A (KIF20A) Antibody |
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20-abx173263 | Abbexa |
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Kinesin Family, Member 5A (KIF5A) Antibody |
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20-abx173264 | Abbexa |
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Kinesin Family, Member 5B (KIF5B) Antibody |
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20-abx173265 | Abbexa |
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Kinesin Light Chain 4 (KLC4) Antibody |
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abx145735-100ug | Abbexa | 100 ug | EUR 469.2 |
Kinesin Light Chain 2 (KLC2) Antibody |
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abx145742-100ug | Abbexa | 100 ug | EUR 469.2 |
Kinesin Light Chain 3 (KLC3) Antibody |
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abx145850-100ug | Abbexa | 100 ug | EUR 469.2 |
Kinesin Light Chain 1 (KLC1) Antibody |
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abx146467-100ug | Abbexa | 100 ug | EUR 469.2 |
Kinesin Family Member 1C (KIF1C) Antibody |
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abx146469-100ug | Abbexa | 100 ug | EUR 469.2 |
Kinesin Family, Member 1A (KIF1A) Antibody |
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abx146470-100ug | Abbexa | 100 ug | EUR 469.2 |
Kinesin Family Member 11 (KIF11) Antibody |
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abx146489-100ug | Abbexa | 100 ug | EUR 469.2 |
Kinesin-Like Protein KIF2C (KIF2C) Antibody |
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abx122782-100ug | Abbexa | 100 ug | EUR 469.2 |
Kinesin-Like Protein KIF3A (KIF3A) Antibody |
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abx122986-100ug | Abbexa | 100 ug | EUR 469.2 |
Kinesin-Like Protein KIFC3 (KIFC3) Antibody |
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20-abx124088 | Abbexa |
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Kinesin Family Member 18A (KIF18A) Antibody |
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20-abx124812 | Abbexa |
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Kinesin-Like Protein KIF23 (KIF23) Antibody |
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20-abx125351 | Abbexa |
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Chromosome-Associated Kinesin KIF4A (KIF4A) Antibody |
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20-abx136089 | Abbexa |
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Kinesin Family Member 1B (KIF1B) Antibody |
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20-abx141515 | Abbexa |
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Kinesin-Like Protein KIF2B (KIF2B) Antibody |
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20-abx141872 | Abbexa |
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Kinesin-Like Protein KIF3A (KIF3A) Antibody |
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20-abx141890 | Abbexa |
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Kinesin Family, Member 5B (KIF5B) Antibody |
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20-abx130104 | Abbexa |
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Kinesin Family, Member 14 (KIF14) Antibody |
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20-abx126054 | Abbexa |
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Kinesin-Like Protein KIF16B (KIF16B) Antibody |
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20-abx126055 | Abbexa |
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Kinesin-Like Protein KIF23 (KIF23) Antibody |
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20-abx126056 | Abbexa |
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Kinesin Family, Member 18A (KIF18A) Antibody |
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20-abx128038 | Abbexa |
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Kinesin Family Member 12 (KIF12) Antibody |
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20-abx113378 | Abbexa |
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Kinesin Family Member 17 (KIF17) Antibody |
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20-abx113379 | Abbexa |
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Kinesin Family, Member 18A (KIF18A) Antibody |
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20-abx113380 | Abbexa |
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Kinesin Family Member 19 (KIF19) Antibody |
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20-abx113381 | Abbexa |
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Kinesin Family Member 1B (KIF1B) Antibody |
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20-abx113382 | Abbexa |
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Kinesin Family Member 1C (KIF1C) Antibody |
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20-abx113383 | Abbexa |
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Kinesin Family, Member 20A (KIF20A) Antibody |
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20-abx113384 | Abbexa |
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Kinesin-Like Protein KIF22 (KIF22) Antibody |
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20-abx113385 | Abbexa |
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Kinesin-Like Protein KIF26B (KIF26B) Antibody |
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20-abx113386 | Abbexa |
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Kinesin-Like Protein KIF2B (KIF2B) Antibody |
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20-abx113387 | Abbexa |
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Kinesin-Like Protein KIF3A (KIF3A) Antibody |
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20-abx113388 | Abbexa |
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Kinesin-Like Protein KIF3C (KIF3C) Antibody |
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20-abx113389 | Abbexa |
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Chromosome-Associated Kinesin KIF4A (KIF4A) Antibody |
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20-abx113390 | Abbexa |
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Kinesin Family, Member 5A (KIF5A) Antibody |
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20-abx113391 | Abbexa |
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Kinesin-Like Protein KIF6 (KIF6) Antibody |
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20-abx113392 | Abbexa |
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Kinesin-Like Protein KIFC1 (KIFC1) Antibody |
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20-abx113393 | Abbexa |
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Kinesin-Like Protein KIFC3 (KIFC3) Antibody |
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20-abx113394 | Abbexa |
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Kinesin-Like Protein KIF2A (KIF2A) Antibody |
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20-abx113395 | Abbexa |
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Kinesin Light Chain 1 (KLC1) Antibody |
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20-abx113396 | Abbexa |
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Kinesin Light Chain 2 (KLC2) Antibody |
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20-abx113397 | Abbexa |
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Kinesin Light Chain 3 (KLC3) Antibody |
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20-abx113398 | Abbexa |
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Kinesin-Associated Protein 3 (KIFAP3) Antibody |
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20-abx113399 | Abbexa |
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Kinesin-Like Protein KIF2B (KIF2B) Antibody |
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20-abx004968 | Abbexa |
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Kinesin Family Member 1B (KIF1B) Antibody |
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20-abx005089 | Abbexa |
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Kinesin-Like Protein KIF3A (KIF3A) Antibody |
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20-abx005090 | Abbexa |
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Kinesin-Like Protein KIF6 (KIF6) Antibody |
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20-abx005884 | Abbexa |
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Kinesin Family Member 11 (KIF11) Antibody |
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20-abx006574 | Abbexa |
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Kinesin Family Member 5A (KIF5A) Antibody |
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20-abx002350 | Abbexa |
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Kinesin-Like Protein KIFC1 (KIFC1) Antibody |
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20-abx002351 | Abbexa |
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Kinesin-Associated Protein 3 (KIFAP3) Antibody |
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20-abx003385 | Abbexa |
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Kinesin Light Chain 2 (KLC2) Antibody |
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20-abx003757 | Abbexa |
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Kinesin-Like Protein KIF2C (KIF2C) Antibody |
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20-abx004172 | Abbexa |
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Kinesin Light Chain 1 (KLC1) Antibody |
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20-abx004251 | Abbexa |
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Chromosome-Associated Kinesin KIF4A (KIF4A) Antibody |
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20-abx014364 | Abbexa |
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Chromosome-Associated Kinesin KIF4A (KIF4A) Antibody |
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20-abx008226 | Abbexa |
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Kinesin Light Chain 2 (KLC2) Antibody |
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abx026678-400ul | Abbexa | 400 ul | EUR 627.6 |
Kinesin Light Chain 2 (KLC2) Antibody |
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abx026678-80l | Abbexa | 80 µl | EUR 343.2 |
Kinesin-Like Protein KIF9 (KIF9) Antibody |
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abx032670-400ul | Abbexa | 400 ul | EUR 627.6 |
Kinesin-Like Protein KIF9 (KIF9) Antibody |
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abx032670-80l | Abbexa | 80 µl | EUR 343.2 |
Kinesin-Like Protein KIF3C (KIF3C) Antibody |
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abx033419-400ul | Abbexa | 400 ul | EUR 627.6 |
Kinesin-Like Protein KIF3C (KIF3C) Antibody |
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abx033419-80l | Abbexa | 80 µl | EUR 343.2 |
Kinesin Light Chain 1 (KLC1) Antibody |
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abx034039-400ul | Abbexa | 400 ul | EUR 627.6 |
Kinesin Light Chain 1 (KLC1) Antibody |
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abx034039-80l | Abbexa | 80 µl | EUR 343.2 |
Kinesin Family Member 11 (KIF11) Antibody |
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abx034225-400ul | Abbexa | 400 ul | EUR 627.6 |
Kinesin Family Member 11 (KIF11) Antibody |
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abx034225-80l | Abbexa | 80 µl | EUR 343.2 |
Kinesin Family Member 18A (KIF18A) Antibody |
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abx028794-400ul | Abbexa | 400 ul | EUR 627.6 |
Kinesin Family Member 18A (KIF18A) Antibody |
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abx028794-80l | Abbexa | 80 µl | EUR 343.2 |
Kinesin Family Member 20A (KIF20A) Antibody |
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abx029233-400ul | Abbexa | 400 ul | EUR 627.6 |
Kinesin Family Member 20A (KIF20A) Antibody |
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abx029233-80l | Abbexa | 80 µl | EUR 343.2 |
Kinesin-Like Protein KIF3B (KIF3B) Antibody |
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abx029384-400ul | Abbexa | 400 ul | EUR 627.6 |
Kinesin-Like Protein KIF3B (KIF3B) Antibody |
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abx029384-80l | Abbexa | 80 µl | EUR 343.2 |
Kinesin Family Member 15 (KIF15) Antibody |
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abx030162-400ul | Abbexa | 400 ul | EUR 627.6 |
Kinesin Family Member 15 (KIF15) Antibody |
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abx030162-80l | Abbexa | 80 µl | EUR 343.2 |
Kinesin-Like Protein KIF3A (KIF3A) Antibody |
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abx030619-400ul | Abbexa | 400 ul | EUR 627.6 |
Kinesin-Like Protein KIF3A (KIF3A) Antibody |
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abx030619-80l | Abbexa | 80 µl | EUR 343.2 |
Kinesin-Like Protein KIF6 (KIF6) Antibody |
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abx034425-400ul | Abbexa | 400 ul | EUR 627.6 |
Kinesin-Like Protein KIF6 (KIF6) Antibody |
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abx034425-80l | Abbexa | 80 µl | EUR 343.2 |
Kinesin-Like Protein KIF27 (KIF27) Antibody |
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abx030737-400ul | Abbexa | 400 ul | EUR 627.6 |
Kinesin-Like Protein KIF27 (KIF27) Antibody |
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abx030737-80l | Abbexa | 80 µl | EUR 343.2 |
Kinesin Family Member 17 (KIF17) Antibody |
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20-abx210333 | Abbexa |
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Kinesin-Like Protein KIF22 (KIF22) Antibody |
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20-abx210334 | Abbexa |
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Trafficking Kinesin Protein 1 (TRAK1) Antibody |
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20-abx210598 | Abbexa |
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Trafficking Kinesin Protein 1 (TRAK1) Antibody |
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20-abx210599 | Abbexa |
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Kinesin Family Member 25 (KIF25) Antibody |
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20-abx210853 | Abbexa |
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Kinesin Family, Member 20A (KIF20A) Antibody |
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20-abx211911 | Abbexa |
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Kinesin-Like Protein KIF3A (KIF3A) Antibody |
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20-abx212358 | Abbexa |
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Chromosome-Associated Kinesin KIF4A (KIF4A) Antibody |
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20-abx212464 | Abbexa |
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Chromosome-Associated Kinesin KIF4A (KIF4A) Antibody |
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20-abx212465 | Abbexa |
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Kinesin-Associated Protein 3 (KIFAP3) Antibody |
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20-abx333719 | Abbexa |
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Kinesin Family Member 15 (KIF15) Antibody |
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20-abx333720 | Abbexa |
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Kinesin-Like Protein KIFC1 (KIFC1) Antibody |
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20-abx333721 | Abbexa |
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Kinesin Family, Member 20A (KIF20A) Antibody |
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20-abx334033 | Abbexa |
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Kinesin Family Member 13B (KIF13B) Antibody |
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20-abx334186 | Abbexa |
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Kinesin Family Member 20B (KIF20B) Antibody |
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20-abx334187 | Abbexa |
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Kinesin-Like Protein KIF22 (KIF22) Antibody |
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20-abx334188 | Abbexa |
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Kinesin Family, Member 5B (KIF5B) Antibody |
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20-abx338851 | Abbexa |
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Kinesin-Like Protein KIF22 (KIF22) Antibody |
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20-abx339573 | Abbexa |
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Kinesin Family Member 20B (KIF20B) Antibody |
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abx330745-100ul | Abbexa | 100 ul | EUR 510 |
Chromosome-Associated Kinesin KIF4A (KIF4A) Antibody |
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abx331012-100ul | Abbexa | 100 ul | EUR 510 |
Human Kinesin 2 (KNS2) CLIA Kit |
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20-abx493763 | Abbexa |
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expert opinion: Many preclinical research studies show that treatment of cells can enhance the function of sensory / motor animals and the show will be very promising for clinical trials. In particular, recent advances have led to development of biomaterials that aims to promote in situ cell delivery. This review dig into this topic discussed the possibility of cell treatment to increase the chances of medical in the repair of the SCI.