Mesenchymal Stem Cell Derived Extracellular Vesicles for Tissue Engineering and Regenerative Medicine Applications.

Mesenchymal stem cells (MSC) are being widely studied for their potential in tissue engineering and regenerative medicine. However, recent evidence suggests that the beneficial effects of MSCs may manifest with them release extracellular vesicles (EV); usually does not require the administration of MSC.

This evidence, particularly from pre-clinical in vitro and in vivo, suggesting that MSC-EVS may indicate a substantial therapeutic properties in various pathophysiological conditions, has the potential to restore a variety of damaged or diseased tissues and organs. These benefits of MSC EVS apparently found, regardless of the origin of the anatomy or body fluids from MSC (and including for example, bone marrow, adipose tissue, umbilical cord, urine, etc.).

In addition, early indications are that the beneficial effects of MSC-EVS can be further improved by modifying the way in which the MSC donor are cultured (eg, in hypoxic compared with normoxic conditions, 3D compared with the format of the culture 2D) and / or if EVs are then bio engineered (eg, loaded with certain). So far, several clinical trials in humans of MSC-EVS has been done and the question unanswered whether a heterogeneous population of EVs profitable or specific sub-populations, how best we can culture and scale-up production of MSC-EV and isolation for clinical utility, and in what format they should be given.

However, as reviewed here, there is now substantial evidence to support the use of MSC-EVS in tissue engineering and regenerative medicine and further research to establish how best to utilize this approach to social and economic benefits justified. The cells secrete extracellular vesicles (EV) which probably has its origins endosomal, or from evaginations of the plasma membrane. The former is usually called exosomes, with sizes ranging from 50 to 100 nm. This EV-containing lipid bilayer membrane protein associated with.

Mesenchymal Stem Cell Derived Extracellular Vesicles for Tissue Engineering and Regenerative Medicine Applications.
Mesenchymal Stem Cell Derived Extracellular Vesicles for Tissue Engineering and Regenerative Medicine Applications.

Status and Future Prospects currently Metabolic Genome-Scale Modeling to Optimize Use of Mesenchymal Stem Cells in Regenerative Medicine.

Mesenchymal stem cells a promising source of replacement tissue to grow externally and immunomodulatory treatment of certain patients. This promise has not been fulfilled in part because of problems the scale of production and the need to maintain the correct phenotype after re-implantation. One aspect extracorporeal growth that can be manipulated to optimize cell growth and differentiation is metabolism. MSC metabolism changes during and in response to differentiation and changes immunomodulators.

MSC metabolism may be associated with functional differences but how this happened and influence MSC function is still unclear. Understanding how metabolism MSC associated with the cell function is important as the availability of metabolites and the state of the environment in the body can affect the success of the implantation. Genome-scale metabolic constraint based modeling can be used as a tool to fill the gap in knowledge about the metabolism of the MSC, to act as a framework to integrate and understand the various types of data (eg, genomic, transcriptomic and metabolomics).

V5 Epitope Tag
5-02067 4 x 5mg Ask for price

T7 epitope tag
AS21-4679 50 µg
EUR 155

S epitope tag
AS21-4684 50 µg
EUR 155

E2 Epitope Tag
MBS611050-004mg 0.04mg
EUR 430

E2 Epitope Tag
MBS611050-01mg 0.1mg
EUR 645

E2 Epitope Tag
MBS611050-5x01mg 5x0.1mg
EUR 2760

V5 Epitope Tag
MBS8247130-10mg 10mg
EUR 645

V5 Epitope Tag
MBS8247130-1mg 1mg
EUR 245

V5 Epitope Tag
MBS8247130-5mg 5mg
EUR 455

V5 Epitope Tag
MBS8247130-5x10mg 5x10mg
EUR 2800

V5 (GKPIPNPLLGLDST epitope tag, GKPIPNPLLGLDST tag, V5 epitope tag)
MBS649020-01mg 0.1mg
EUR 540

V5 (GKPIPNPLLGLDST epitope tag, GKPIPNPLLGLDST tag, V5 epitope tag)
MBS649020-5x01mg 5x0.1mg
EUR 2275

KT3 epitope tag
AS21-4680 50 µg
EUR 155

HSV epitope tag
AS21-4681 50 µg
EUR 155

Myc epitope tag
AS21-4685 50 µg
EUR 155

CBP epitope tag
AS21-4686 50 µg
EUR 155

TAP epitope tag
AS21-4687 50 µg
EUR 155

Dengue Epitope 10
den-042 100µg
EUR 165
Description: Recombinant Dengue Multiple Epitopes 10

Dengue Epitope 13
den-043 100µg
EUR 165
Description: Recombinant Dengue Multiple Epitopes 13

T Epitope, Serinyl
T020000 10mg
EUR 2325

V5 (GKPIPNPLLGLDST epitope tag, GKPIPNPLLGLDST tag, V5 epitope tag) (HRP)
MBS646971-004mg 0.04mg
EUR 430

V5 (GKPIPNPLLGLDST epitope tag, GKPIPNPLLGLDST tag, V5 epitope tag) (HRP)
MBS646971-01mg 0.1mg
EUR 575

V5 (GKPIPNPLLGLDST epitope tag, GKPIPNPLLGLDST tag, V5 epitope tag) (HRP)
MBS646971-5x01mg 5x0.1mg
EUR 2435

V5 (GKPIPNPLLGLDST epitope tag, GKPIPNPLLGLDST tag, V5 epitope tag) (HRP)
MBS6008371-004mg 0.04mg
EUR 430

V5 (GKPIPNPLLGLDST epitope tag, GKPIPNPLLGLDST tag, V5 epitope tag) (HRP)
MBS6008371-5x004mg 5x0.04mg
EUR 1790

T7 (MASMTGGQQMG, MASMTGGQQMG Epitope Tag, MASMTGGQQMG Tag, T7 Epitope Tag)
MBS642777-01mg 0.1mg
EUR 575

T7 (MASMTGGQQMG, MASMTGGQQMG Epitope Tag, MASMTGGQQMG Tag, T7 Epitope Tag)
MBS642777-5x01mg 5x0.1mg
EUR 2430

FLAG Epitope Peptide
H-6284.0001 1.0mg
EUR 135.6
Description: Sum Formula: C41H60N10O20; CAS# [98849-88-8] net

FLAG Epitope Peptide
H-6284.0005 5.0mg
EUR 283.2
Description: Sum Formula: C41H60N10O20; CAS# [98849-88-8] net

FLAG Epitope Peptide
H-6284.0025 25.0mg
EUR 1023.6
Description: Sum Formula: C41H60N10O20; CAS# [98849-88-8] net

FLAG Epitope Peptide
H-7748.0500 0.5mg
EUR 64.8
Description: Sum Formula: C41H60N10O20; CAS# [98849-88-8] net

FLAG Epitope Peptide
H-7748.1000 1.0mg
EUR 85.2
Description: Sum Formula: C41H60N10O20; CAS# [98849-88-8] net

DYKDDDDK-Tag (DDDDK Epitope Tag, DYKDDDDK Epitope Tag, DYKDDDDK tag, ECS Epitope Tag, ECS tag, Enterokinase Cleavage Site Epitope Tag, Enterokinase Cleavage Site tag, DYKDDDDK) (AP)
MBS6257486-01mL 0.1mL
EUR 980

DYKDDDDK-Tag (DDDDK Epitope Tag, DYKDDDDK Epitope Tag, DYKDDDDK tag, ECS Epitope Tag, ECS tag, Enterokinase Cleavage Site Epitope Tag, Enterokinase Cleavage Site tag, DYKDDDDK) (AP)
MBS6257486-5x01mL 5x0.1mL
EUR 4250

DYKDDDDK-Tag (DDDDK Epitope Tag, DYKDDDDK Epitope Tag, DYKDDDDK tag, ECS Epitope Tag, ECS tag, Enterokinase Cleavage Site Epitope Tag, Enterokinase Cleavage Site tag, DYKDDDDK) (PE)
MBS6257646-01mL 0.1mL
EUR 980

DYKDDDDK-Tag (DDDDK Epitope Tag, DYKDDDDK Epitope Tag, DYKDDDDK tag, ECS Epitope Tag, ECS tag, Enterokinase Cleavage Site Epitope Tag, Enterokinase Cleavage Site tag, DYKDDDDK) (PE)
MBS6257646-5x01mL 5x0.1mL
EUR 4250

Rhodopsin Epitope Tag
HY-P1509 1mg
EUR 183.6

Rhodopsin Epitope Tag
TP1865-10mg 10mg Ask for price
Description: Rhodopsin Epitope Tag

Rhodopsin Epitope Tag
TP1865-1g 1g Ask for price
Description: Rhodopsin Epitope Tag

Rhodopsin Epitope Tag
TP1865-1mg 1mg Ask for price
Description: Rhodopsin Epitope Tag

Rhodopsin Epitope Tag
TP1865-50mg 50mg Ask for price
Description: Rhodopsin Epitope Tag

Rhodopsin Epitope Tag
TP1865-5mg 5mg Ask for price
Description: Rhodopsin Epitope Tag

Rhodopsin Epitope Tag
MBS5763864-10mg 10mg
EUR 385

Rhodopsin Epitope Tag
MBS5763864-1mg 1mg
EUR 160

Rhodopsin Epitope Tag
MBS5763864-5mg 5mg
EUR 275

Rhodopsin Epitope Tag
MBS5763864-5x10mg 5x10mg
EUR 1585

CD41/CD61 (PAC-1 epitope) (CD41/CD61 (PAC-1 epitope)) Antibody (PerCP)
abx347144-100l 100 µl Ask for price

CD41/CD61 (PAC-1 epitope) (CD41/CD61 (PAC-1 epitope)) Antibody (PerCP)
abx347144-50l 50 µl
EUR 400

DYKDDDDK-Tag (DDDDK Epitope Tag, DYKDDDDK Epitope Tag, DYKDDDDK tag, ECS Epitope Tag, ECS tag, Enterokinase Cleavage Site Epitope Tag, Enterokinase Cleavage Site tag, DYKDDDDK)(Biotin)
MBS6507417-01mg 0.1mg
EUR 845

DYKDDDDK-Tag (DDDDK Epitope Tag, DYKDDDDK Epitope Tag, DYKDDDDK tag, ECS Epitope Tag, ECS tag, Enterokinase Cleavage Site Epitope Tag, Enterokinase Cleavage Site tag, DYKDDDDK)(Biotin)
MBS6507417-5x01mg 5x0.1mg
EUR 3660

DYKDDDDK-Tag (DDDDK Epitope Tag, DYKDDDDK Epitope Tag, DYKDDDDK tag, ECS Epitope Tag, ECS tag, Enterokinase Cleavage Site Epitope Tag, Enterokinase Cleavage Site tag, DYKDDDDK) (APC)
MBS6257518-01mL 0.1mL
EUR 980

DYKDDDDK-Tag (DDDDK Epitope Tag, DYKDDDDK Epitope Tag, DYKDDDDK tag, ECS Epitope Tag, ECS tag, Enterokinase Cleavage Site Epitope Tag, Enterokinase Cleavage Site tag, DYKDDDDK) (APC)
MBS6257518-5x01mL 5x0.1mL
EUR 4250

DYKDDDDK-Tag (DDDDK Epitope Tag, DYKDDDDK Epitope Tag, DYKDDDDK tag, ECS Epitope Tag, ECS tag, Enterokinase Cleavage Site Epitope Tag, Enterokinase Cleavage Site tag, DYKDDDDK) (Biotin)
MBS6257550-01mL 0.1mL
EUR 980

DYKDDDDK-Tag (DDDDK Epitope Tag, DYKDDDDK Epitope Tag, DYKDDDDK tag, ECS Epitope Tag, ECS tag, Enterokinase Cleavage Site Epitope Tag, Enterokinase Cleavage Site tag, DYKDDDDK) (Biotin)
MBS6257550-5x01mL 5x0.1mL
EUR 4250

DYKDDDDK-Tag (DDDDK Epitope Tag, DYKDDDDK Epitope Tag, DYKDDDDK tag, ECS Epitope Tag, ECS tag, Enterokinase Cleavage Site Epitope Tag, Enterokinase Cleavage Site tag, DYKDDDDK) (FITC)
MBS6257582-01mL 0.1mL
EUR 980

DYKDDDDK-Tag (DDDDK Epitope Tag, DYKDDDDK Epitope Tag, DYKDDDDK tag, ECS Epitope Tag, ECS tag, Enterokinase Cleavage Site Epitope Tag, Enterokinase Cleavage Site tag, DYKDDDDK) (FITC)
MBS6257582-5x01mL 5x0.1mL
EUR 4250

DYKDDDDK-Tag (DDDDK Epitope Tag, DYKDDDDK Epitope Tag, DYKDDDDK tag, ECS Epitope Tag, ECS tag, Enterokinase Cleavage Site Epitope Tag, Enterokinase Cleavage Site tag, DYKDDDDK) (HRP)
MBS6257614-01mL 0.1mL
EUR 980

DYKDDDDK-Tag (DDDDK Epitope Tag, DYKDDDDK Epitope Tag, DYKDDDDK tag, ECS Epitope Tag, ECS tag, Enterokinase Cleavage Site Epitope Tag, Enterokinase Cleavage Site tag, DYKDDDDK) (HRP)
MBS6257614-5x01mL 5x0.1mL
EUR 4250

DYKDDDDK Epitope Peptide
4034775.0001 1 mg
EUR 62.9

DYKDDDDK Epitope Peptide
4034775.0005 5 mg
EUR 159.5

DYKDDDDK Epitope Peptide
4034775.0025 25 mg
EUR 637.04

DYKDDDDK Epitope Peptide
4044101.05 0.5 mg
EUR 17.96

DYKDDDDK Epitope Peptide
4044101.1 1 mg
EUR 32.55

c-Myc epitope tag
MBS622082-01mg 0.1mg
EUR 690

c-Myc epitope tag
MBS622082-5x01mg 5x0.1mg
EUR 2955

DYKDDDDK-Tag (DDDDK Epitope Tag, DYKDDDDK Epitope Tag, DYKDDDDK tag, ECS Epitope Tag, ECS tag, Enterokinase Cleavage Site Epitope Tag, Enterokinase Cleavage Site tag, DYKDDDDK) (MaxLight 405)
MBS6257678-01mL 0.1mL
EUR 980

DYKDDDDK-Tag (DDDDK Epitope Tag, DYKDDDDK Epitope Tag, DYKDDDDK tag, ECS Epitope Tag, ECS tag, Enterokinase Cleavage Site Epitope Tag, Enterokinase Cleavage Site tag, DYKDDDDK) (MaxLight 405)
MBS6257678-5x01mL 5x0.1mL
EUR 4250

DYKDDDDK-Tag (DDDDK Epitope Tag, DYKDDDDK Epitope Tag, DYKDDDDK tag, ECS Epitope Tag, ECS tag, Enterokinase Cleavage Site Epitope Tag, Enterokinase Cleavage Site tag, DYKDDDDK) (MaxLight 490)
MBS6257710-01mL 0.1mL
EUR 980

DYKDDDDK-Tag (DDDDK Epitope Tag, DYKDDDDK Epitope Tag, DYKDDDDK tag, ECS Epitope Tag, ECS tag, Enterokinase Cleavage Site Epitope Tag, Enterokinase Cleavage Site tag, DYKDDDDK) (MaxLight 490)
MBS6257710-5x01mL 5x0.1mL
EUR 4250

DYKDDDDK-Tag (DDDDK Epitope Tag, DYKDDDDK Epitope Tag, DYKDDDDK tag, ECS Epitope Tag, ECS tag, Enterokinase Cleavage Site Epitope Tag, Enterokinase Cleavage Site tag, DYKDDDDK) (MaxLight 550)
MBS6257742-01mL 0.1mL
EUR 980

DYKDDDDK-Tag (DDDDK Epitope Tag, DYKDDDDK Epitope Tag, DYKDDDDK tag, ECS Epitope Tag, ECS tag, Enterokinase Cleavage Site Epitope Tag, Enterokinase Cleavage Site tag, DYKDDDDK) (MaxLight 550)
MBS6257742-5x01mL 5x0.1mL
EUR 4250

DYKDDDDK-Tag (DDDDK Epitope Tag, DYKDDDDK Epitope Tag, DYKDDDDK tag, ECS Epitope Tag, ECS tag, Enterokinase Cleavage Site Epitope Tag, Enterokinase Cleavage Site tag, DYKDDDDK) (MaxLight 650)
MBS6257774-01mL 0.1mL
EUR 980

DYKDDDDK-Tag (DDDDK Epitope Tag, DYKDDDDK Epitope Tag, DYKDDDDK tag, ECS Epitope Tag, ECS tag, Enterokinase Cleavage Site Epitope Tag, Enterokinase Cleavage Site tag, DYKDDDDK) (MaxLight 650)
MBS6257774-5x01mL 5x0.1mL
EUR 4250

DYKDDDDK-Tag (DDDDK Epitope Tag, DYKDDDDK Epitope Tag, DYKDDDDK tag, ECS Epitope Tag, ECS tag, Enterokinase Cleavage Site Epitope Tag, Enterokinase Cleavage Site tag, DYKDDDDK) (MaxLight 750)
MBS6257806-01mL 0.1mL
EUR 980

DYKDDDDK-Tag (DDDDK Epitope Tag, DYKDDDDK Epitope Tag, DYKDDDDK tag, ECS Epitope Tag, ECS tag, Enterokinase Cleavage Site Epitope Tag, Enterokinase Cleavage Site tag, DYKDDDDK) (MaxLight 750)
MBS6257806-5x01mL 5x0.1mL
EUR 4250

B (QYPALT) Epitope Tag
MBS6006135-004mg 0.04mg
EUR 430

B (QYPALT) Epitope Tag
MBS6006135-5x004mg 5x0.04mg
EUR 1790

Universal TT epitope P2 (830-844)
5-02048 4 x 1mg Ask for price

Universal TT epitope P2 (830-844)
MBS826674-10mg 10mg
EUR 490

Universal TT epitope P2 (830-844)
MBS826674-1mg 1mg
EUR 190

Universal TT epitope P2 (830-844)
MBS826674-5mg 5mg
EUR 330

Universal TT epitope P2 (830-844)
MBS826674-5x10mg 5x10mg
EUR 2130

C- Myc peptide epitope
5-00879 4 x 1mg Ask for price

V5 Epitope Tag Peptide
20-abx265817
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  • 10 mg
  • 25 mg
  • 5 mg

V5 Epitope Tag Peptide
A6005-25 25 mg
EUR 435
Description: Peptide sequence-GKPIPNPLLGLDST

V5 Epitope Tag Peptide
A6005-5 5 mg
EUR 96
Description: Peptide sequence-GKPIPNPLLGLDST

V5 Epitope Tag Peptide
abx265817-100tests 100 tests
EUR 212.5

V5 Epitope Tag Peptide
abx265817-200tests 200 tests
EUR 287.5

V5 Epitope Tag Peptide
abx265817-500tests 500 tests
EUR 462.5

C Myc peptide epitope
abx266620-1ml 1 ml
EUR 337.5

C Myc peptide epitope
abx266620-200l 200 µl
EUR 187.5

V5 Epitope Tag Peptide
TP2189-10mg 10mg Ask for price
Description: V5 Epitope Tag Peptide

V5 Epitope Tag Peptide
TP2189-1g 1g Ask for price
Description: V5 Epitope Tag Peptide

V5 Epitope Tag Peptide
TP2189-1mg 1mg Ask for price
Description: V5 Epitope Tag Peptide

V5 Epitope Tag Peptide
TP2189-50mg 50mg Ask for price
Description: V5 Epitope Tag Peptide

V5 Epitope Tag Peptide
TP2189-5mg 5mg Ask for price
Description: V5 Epitope Tag Peptide

V5 Epitope Tag Peptide
MBS5764156-5mg 5mg
EUR 190

V5 Epitope Tag Peptide
MBS5764156-5x5mg 5x5mg
EUR 705

T7 Epitope -Tag Antibody
3987-100 each
EUR 405.6

T7 Epitope -Tag Antibody
3987-30T each
EUR 175.2

T7 Epitope tag antibody
70R-12233 100 ug
EUR 371
Description: Rabbit polyclonal T7 Epitope tag antibody

T7 Epitope tag antibody
MBS835078-01mg 0.1mg
EUR 505

T7 Epitope tag antibody
MBS835078-5x01mg 5x0.1mg
EUR 2225

HBeAg "e" Epitope Protein
abx060548-100ug 100 ug
EUR 1629.6

HBeAg "e" Epitope Protein
abx060548-100g 100 µg Ask for price

HBeAg "e" Epitope Protein
abx060548-10g 10 µg
EUR 2025

HBeAg "e" Epitope Protein
abx060548-50g 50 µg Ask for price

S1 (NANNPDWDF) Epitope Tag
MBS644661-004mg 0.04mg
EUR 430

S1 (NANNPDWDF) Epitope Tag
MBS644661-5x004mg 5x0.04mg
EUR 1790

Prolactin, Epitope C (PRL)
MBS633072-05mg 0.5mg
EUR 1065

Prolactin, Epitope C (PRL)
MBS633072-5x05mg 5x0.5mg
EUR 4640

HPV16-E711-20 epitope
TP1515-10mg 10mg Ask for price
Description: HPV16-E711-20 epitope

HPV16-E711-20 epitope
TP1515-1g 1g Ask for price
Description: HPV16-E711-20 epitope

HPV16-E711-20 epitope
TP1515-1mg 1mg Ask for price
Description: HPV16-E711-20 epitope

HPV16-E711-20 epitope
TP1515-50mg 50mg Ask for price
Description: HPV16-E711-20 epitope

HPV16-E711-20 epitope
TP1515-5mg 5mg Ask for price
Description: HPV16-E711-20 epitope

HPV16-E711-20 epitope
MBS5789240-INQUIRE INQUIRE Ask for price

Coxsackie Virus B3 Epitope
MBS659927-1mg 1mg
EUR 610

Coxsackie Virus B3 Epitope
MBS659927-5x1mg 5x1mg
EUR 2600

Epitope Unmasking Buffer 10X
21760005-1 250 mL
EUR 60.54

Epitope Unmasking Buffer 10X
21760005-2 1 L
EUR 134.09

Universal (HTTPHH) Epitope Tag
MBS612377-004mg 0.04mg
EUR 430

Universal (HTTPHH) Epitope Tag
MBS612377-01mg 0.1mg
EUR 575

Universal (HTTPHH) Epitope Tag
MBS612377-5x01mg 5x0.1mg
EUR 2435

Prolactin (Epitope b) Antibody
GWB-FA6045 0.5 mg Ask for price

Prolactin (Epitope c) Antibody
GWB-FCF8CE 0.5 mg Ask for price

Rhodopsin Epitope Tag acetate
TP1865L-10mg 10mg Ask for price
Description: Rhodopsin Epitope Tag acetate

Rhodopsin Epitope Tag acetate
TP1865L-1g 1g Ask for price
Description: Rhodopsin Epitope Tag acetate

Rhodopsin Epitope Tag acetate
TP1865L-1mg 1mg Ask for price
Description: Rhodopsin Epitope Tag acetate

Rhodopsin Epitope Tag acetate
TP1865L-50mg 50mg Ask for price
Description: Rhodopsin Epitope Tag acetate

Rhodopsin Epitope Tag acetate
TP1865L-5mg 5mg Ask for price
Description: Rhodopsin Epitope Tag acetate

Rhodopsin Epitope Tag acetate
MBS5765472-10mg 10mg
EUR 435

Rhodopsin Epitope Tag acetate
MBS5765472-1mg 1mg
EUR 165

Rhodopsin Epitope Tag acetate
MBS5765472-25mg 25mg
EUR 715

Rhodopsin Epitope Tag acetate
MBS5765472-50mg 50mg
EUR 970

Rhodopsin Epitope Tag acetate
MBS5765472-5mg 5mg
EUR 300

V5 epitope Polyclonal Antibody
MBS448027-06mg 0.6mg
EUR 330

V5 epitope Polyclonal Antibody
MBS448027-15mg 1.5mg
EUR 450

V5 epitope Polyclonal Antibody
MBS448027-5x15mg 5x1.5mg
EUR 1980

Hepatitis B Ag. e epitope
GWB-45D6EF 1 mg Ask for price

CD3 (activation epitope) Antibody
abx139107-01mg 0.1 mg
EUR 460.8

CD3 (activation epitope) Antibody
abx139107-100l 100 µl
EUR 300

CD3 (activation epitope) Antibody
abx139107-500l 500 µl Ask for price

Universal TT epitope P2 (830-844) Peptide
abx266549-1ml 1 ml
EUR 250

Universal TT epitope P2 (830-844) Peptide
abx266549-200l 200 µl
EUR 187.5

c-Myc Epitope Protein (OVA)
20-abx651284
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

This approach has long been used to optimize the growth and productivity of bacteria and the production system is being increasingly used to provide insights into human health research. Production of tissue for implantation using a well-optimized MSC requires mass production of cells and understanding of patients and specific phenotypes metabolism situation. This review considers the current knowledge of the metabolism of the MSC and how it can be optimized with the use of current and future genome-scale metabolic modeling based constraints to further this goal.