Mesenchymal Stem Cell Derived Extracellular Vesicles for Tissue Engineering and Regenerative Medicine Applications.

Mesenchymal stem cells (MSC) are being widely studied for their potential in tissue engineering and regenerative medicine. However, recent evidence suggests that the beneficial effects of MSCs may manifest with them release extracellular vesicles (EV); usually does not require the administration of MSC.

This evidence, particularly from pre-clinical in vitro and in vivo, suggesting that MSC-EVS may indicate a substantial therapeutic properties in various pathophysiological conditions, has the potential to restore a variety of damaged or diseased tissues and organs. These benefits of MSC EVS apparently found, regardless of the origin of the anatomy or body fluids from MSC (and including for example, bone marrow, adipose tissue, umbilical cord, urine, etc.).

In addition, early indications are that the beneficial effects of MSC-EVS can be further improved by modifying the way in which the MSC donor are cultured (eg, in hypoxic compared with normoxic conditions, 3D compared with the format of the culture 2D) and / or if EVs are then bio engineered (eg, loaded with certain). So far, several clinical trials in humans of MSC-EVS has been done and the question unanswered whether a heterogeneous population of EVs profitable or specific sub-populations, how best we can culture and scale-up production of MSC-EV and isolation for clinical utility, and in what format they should be given.

However, as reviewed here, there is now substantial evidence to support the use of MSC-EVS in tissue engineering and regenerative medicine and further research to establish how best to utilize this approach to social and economic benefits justified. The cells secrete extracellular vesicles (EV) which probably has its origins endosomal, or from evaginations of the plasma membrane. The former is usually called exosomes, with sizes ranging from 50 to 100 nm. This EV-containing lipid bilayer membrane protein associated with.

 Mesenchymal Stem Cell Derived Extracellular Vesicles for Tissue Engineering and Regenerative Medicine Applications.
Mesenchymal Stem Cell Derived Extracellular Vesicles for Tissue Engineering and Regenerative Medicine Applications.

Status and Future Prospects currently Metabolic Genome-Scale Modeling to Optimize Use of Mesenchymal Stem Cells in Regenerative Medicine.

Mesenchymal stem cells a promising source of replacement tissue to grow externally and immunomodulatory treatment of certain patients. This promise has not been fulfilled in part because of problems the scale of production and the need to maintain the correct phenotype after re-implantation. One aspect extracorporeal growth that can be manipulated to optimize cell growth and differentiation is metabolism. MSC metabolism changes during and in response to differentiation and changes immunomodulators.

MSC metabolism may be associated with functional differences but how this happened and influence MSC function is still unclear. Understanding how metabolism MSC associated with the cell function is important as the availability of metabolites and the state of the environment in the body can affect the success of the implantation. Genome-scale metabolic constraint based modeling can be used as a tool to fill the gap in knowledge about the metabolism of the MSC, to act as a framework to integrate and understand the various types of data (eg, genomic, transcriptomic and metabolomics).

Dengue Epitope 13

den-043 100µg
EUR 165
Description: Recombinant Dengue Multiple Epitopes 13

T Epitope, Serinyl

T020000 10mg
EUR 2325

FLAG Epitope Peptide

H-6284.0001 1.0mg
EUR 135.6
Description: Sum Formula: C41H60N10O20; CAS# [98849-88-8] net

FLAG Epitope Peptide

H-6284.0005 5.0mg
EUR 283.2
Description: Sum Formula: C41H60N10O20; CAS# [98849-88-8] net

FLAG Epitope Peptide

H-6284.0025 25.0mg
EUR 1023.6
Description: Sum Formula: C41H60N10O20; CAS# [98849-88-8] net

FLAG Epitope Peptide

H-7748.0500 0.5mg
EUR 64.8
Description: Sum Formula: C41H60N10O20; CAS# [98849-88-8] net

FLAG Epitope Peptide

H-7748.1000 1.0mg
EUR 85.2
Description: Sum Formula: C41H60N10O20; CAS# [98849-88-8] net

Rhodopsin Epitope Tag

HY-P1509 1mg
EUR 183.6

Rhodopsin Epitope Tag

TP1865-10mg 10mg Ask for price
Description: Rhodopsin Epitope Tag

Rhodopsin Epitope Tag

TP1865-1g 1g Ask for price
Description: Rhodopsin Epitope Tag

Rhodopsin Epitope Tag

TP1865-1mg 1mg Ask for price
Description: Rhodopsin Epitope Tag

Rhodopsin Epitope Tag

TP1865-50mg 50mg Ask for price
Description: Rhodopsin Epitope Tag

Rhodopsin Epitope Tag

TP1865-5mg 5mg Ask for price
Description: Rhodopsin Epitope Tag

CD41/CD61 (PAC-1 epitope) (CD41/CD61 (PAC-1 epitope)) Antibody (PerCP)

abx347144-100l 100 µl Ask for price

CD41/CD61 (PAC-1 epitope) (CD41/CD61 (PAC-1 epitope)) Antibody (PerCP)

abx347144-50l 50 µl
EUR 400

DYKDDDDK Epitope Peptide

4044101.05 0.5 mg
EUR 17.96

DYKDDDDK Epitope Peptide

4044101.1 1 mg
EUR 32.55

DYKDDDDK Epitope Peptide

4034775.0001 1 mg
EUR 62.9

DYKDDDDK Epitope Peptide

4034775.0005 5 mg
EUR 159.5

DYKDDDDK Epitope Peptide

4034775.0025 25 mg
EUR 637.04

Universal TT epitope P2 (830-844)

5-02048 4 x 1mg Ask for price

V5 Epitope Tag Peptide

20-abx265817
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C- Myc peptide epitope

5-00879 4 x 1mg Ask for price

V5 Epitope Tag Peptide

A6005-25 25 mg
EUR 435
Description: Peptide sequence-GKPIPNPLLGLDST

V5 Epitope Tag Peptide

A6005-5 5 mg
EUR 96
Description: Peptide sequence-GKPIPNPLLGLDST

V5 Epitope Tag Peptide

TP2189-10mg 10mg Ask for price
Description: V5 Epitope Tag Peptide

V5 Epitope Tag Peptide

TP2189-1g 1g Ask for price
Description: V5 Epitope Tag Peptide

V5 Epitope Tag Peptide

TP2189-1mg 1mg Ask for price
Description: V5 Epitope Tag Peptide

V5 Epitope Tag Peptide

TP2189-50mg 50mg Ask for price
Description: V5 Epitope Tag Peptide

V5 Epitope Tag Peptide

TP2189-5mg 5mg Ask for price
Description: V5 Epitope Tag Peptide

V5 Epitope Tag Peptide

abx265817-100tests 100 tests
EUR 212.5

V5 Epitope Tag Peptide

abx265817-200tests 200 tests
EUR 287.5

V5 Epitope Tag Peptide

abx265817-500tests 500 tests
EUR 462.5

C Myc peptide epitope

abx266620-1ml 1 ml
EUR 337.5

C Myc peptide epitope

abx266620-200l 200 µl
EUR 187.5

T7 Epitope -Tag Antibody

3987-100 each
EUR 405.6

T7 Epitope -Tag Antibody

3987-30T each
EUR 175.2

T7 Epitope tag antibody

70R-12233 100 ug
EUR 371
Description: Rabbit polyclonal T7 Epitope tag antibody

HBeAg "e" Epitope Protein

abx060548-100ug 100 ug
EUR 1629.6

HBeAg "e" Epitope Protein

abx060548-100g 100 µg Ask for price

HBeAg "e" Epitope Protein

abx060548-10g 10 µg
EUR 2025

HBeAg "e" Epitope Protein

abx060548-50g 50 µg Ask for price

HPV16-E711-20 epitope

TP1515-10mg 10mg Ask for price
Description: HPV16-E711-20 epitope

HPV16-E711-20 epitope

TP1515-1g 1g Ask for price
Description: HPV16-E711-20 epitope

HPV16-E711-20 epitope

TP1515-1mg 1mg Ask for price
Description: HPV16-E711-20 epitope

HPV16-E711-20 epitope

TP1515-50mg 50mg Ask for price
Description: HPV16-E711-20 epitope

HPV16-E711-20 epitope

TP1515-5mg 5mg Ask for price
Description: HPV16-E711-20 epitope

Epitope Unmasking Buffer 10X

21760005-1 250 mL
EUR 60.54

Epitope Unmasking Buffer 10X

21760005-2 1 L
EUR 134.09

Prolactin (Epitope b) Antibody

GWB-FA6045 0.5 mg Ask for price

Prolactin (Epitope c) Antibody

GWB-FCF8CE 0.5 mg Ask for price

Rhodopsin Epitope Tag acetate

TP1865L-10mg 10mg Ask for price
Description: Rhodopsin Epitope Tag acetate

Rhodopsin Epitope Tag acetate

TP1865L-1g 1g Ask for price
Description: Rhodopsin Epitope Tag acetate

Rhodopsin Epitope Tag acetate

TP1865L-1mg 1mg Ask for price
Description: Rhodopsin Epitope Tag acetate

Rhodopsin Epitope Tag acetate

TP1865L-50mg 50mg Ask for price
Description: Rhodopsin Epitope Tag acetate

Rhodopsin Epitope Tag acetate

TP1865L-5mg 5mg Ask for price
Description: Rhodopsin Epitope Tag acetate

Hepatitis B Ag. e epitope

GWB-45D6EF 1 mg Ask for price

Universal TT epitope P2 (830-844) Peptide

abx266549-1ml 1 ml
EUR 250

Universal TT epitope P2 (830-844) Peptide

abx266549-200l 200 µl
EUR 187.5

c-Myc Epitope Protein (OVA)

20-abx651284
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C-MYC PEPTIDE EPITOPE TFA

TP2311-10mg 10mg Ask for price
Description: C-MYC PEPTIDE EPITOPE TFA

C-MYC PEPTIDE EPITOPE TFA

TP2311-1g 1g Ask for price
Description: C-MYC PEPTIDE EPITOPE TFA

C-MYC PEPTIDE EPITOPE TFA

TP2311-1mg 1mg Ask for price
Description: C-MYC PEPTIDE EPITOPE TFA

C-MYC PEPTIDE EPITOPE TFA

TP2311-50mg 50mg Ask for price
Description: C-MYC PEPTIDE EPITOPE TFA

C-MYC PEPTIDE EPITOPE TFA

TP2311-5mg 5mg Ask for price
Description: C-MYC PEPTIDE EPITOPE TFA

c-Myc Epitope Peptide (OVA)

abx651284-100g 100 µg
EUR 1550

c-Myc Epitope Peptide (OVA)

abx651284-10g 10 µg
EUR 425

c-Myc Epitope Peptide (OVA)

abx651284-50g 50 µg
EUR 500

CD3 (activation epitope) Antibody

abx139107-01mg 0.1 mg
EUR 460.8

CD3 (activation epitope) Antibody

abx139107-100l 100 µl
EUR 300

CD3 (activation epitope) Antibody

abx139107-500l 500 µl Ask for price

hCG (beta 7 Epitope) Antibody

GWB-2209D8 0.5 mg Ask for price

hCG (beta 4 Epitope) Antibody

GWB-2C8496 0.5 mg Ask for price

c-Myc Epitope (Myc) Antibody

20-abx130438
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

c-Myc Epitope (Myc) Antibody

20-abx132269
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  • 100 ug
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  • 1 mg
  • 200 ug
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hCG (beta 1 Epitope) Antibody

GWB-663632 0.5 mg Ask for price

hCG (HOLO C3 Epitope) Antibody

GWB-DE186E 0.5 mg Ask for price

hCG (beta 2 Epitope) Antibody

GWB-7879E4 0.5 mg Ask for price

c-Myc Epitope (Myc) Antibody

abx130438-100l 100 µl
EUR 850

c-Myc Epitope (Myc) Antibody

abx130438-1ml 1 ml Ask for price

c-Myc Epitope (Myc) Antibody

abx130438-200l 200 µl Ask for price

c-Myc Epitope (Myc) Antibody

abx132269-100tests 100 tests
EUR 850

CD18 (Activation Epitope) Antibody

GWB-9C757A 0.02 mg Ask for price

CD18 (Activation Epitope) Antibody

GWB-778F3E 0.2 mg Ask for price

Anti- C-MYC Epitope Antibody

GWB-518893 0.1 ml Ask for price

hCG (alpha 4 Epitope) Antibody

GWB-31D4B0 0.5 mg Ask for price

hCG (alpha 3 Epitope) Antibody

GWB-96D2C5 0.5 mg Ask for price

hCG (alpha 6 Epitope) Antibody

GWB-80E3F5 0.5 mg Ask for price

Anti- C-MYC Epitope Antibody

GWB-8444A3 0.1 mg Ask for price

hCG (alpha 5 Epitope) Antibody

GWB-8C2D8C 0.5 mg Ask for price

hCG (alpha 2 Epitope) Antibody

GWB-960921 0.5 mg Ask for price

CD11b activation epitope Antibody

abx140366-01mg 0.1 mg
EUR 427.2

CD11b activation epitope Antibody

abx140396-01mg 0.1 mg
EUR 427.2

CD11b activation epitope Antibody

abx140366-100g 100 µg
EUR 275

CD11b activation epitope Antibody

abx140396-100g 100 µg
EUR 275

Anti-HA EPITOPE TAG Antibody

GWB-6149E8 100 ug Ask for price

V5 Epitope Tag Peptide acetate

TP2189L-10mg 10mg Ask for price
Description: V5 Epitope Tag Peptide acetate

V5 Epitope Tag Peptide acetate

TP2189L-1g 1g Ask for price
Description: V5 Epitope Tag Peptide acetate

V5 Epitope Tag Peptide acetate

TP2189L-1mg 1mg Ask for price
Description: V5 Epitope Tag Peptide acetate

V5 Epitope Tag Peptide acetate

TP2189L-50mg 50mg Ask for price
Description: V5 Epitope Tag Peptide acetate

V5 Epitope Tag Peptide acetate

TP2189L-5mg 5mg Ask for price
Description: V5 Epitope Tag Peptide acetate

V5 Epitope Tag Peptide Antibody

abx023335-100ug 100 ug
EUR 560.4

IV9 (476 - 484), HIV - 1 RT Epitope

5-01412 4 x 5mg Ask for price

HA Epitope Tag YPYDVPDYA Antibody

abx023312-100ug 100 ug
EUR 460.8

HA Epitope Tag YPYDVPDYA Antibody

abx023312-400l 400 µl Ask for price

HA Epitope Tag YPYDVPDYA Antibody

abx023312-80l 80 µl
EUR 887.5

CD3 (activation epitope) Antibody (PE)

abx139119-01mg 0.1 mg
EUR 577.2

CD3 (activation epitope) Antibody (PE)

abx139119-100l 100 µl
EUR 400

CD3 (activation epitope) Antibody (PE)

abx139119-500l 500 µl Ask for price

CD3 activation epitope Antibody (APC)

abx140478-01mg 0.1 mg
EUR 577.2

CD3 activation epitope Antibody (APC)

abx140478-100g 100 µg
EUR 400

Cd18 (Activation Epitope) Antibody (RPE)

GWB-17EC2C 100 TESTS Ask for price

CD11b Activation Epitope Antibody (PE)

abx140359-100tests 100 tests
EUR 577.2

CD3 activation epitope Antibody (FITC)

abx140488-01mg 0.1 mg
EUR 510

CD18 (Activation Epitope) Antibody (RPE)

GWB-Q01003 25 TESTS Ask for price

CD3 activation epitope Antibody (FITC)

abx140488-100g 100 µg
EUR 350

CD11b Activation Epitope Antibody (PE)

abx140359-100g 100 µg
EUR 400

Cd18 (Activation Epitope) Antibody (FITC)

GWB-550993 0.025 mg Ask for price

Cd18 (Activation Epitope) Antibody (FITC)

GWB-56BD51 0.1 mg Ask for price

Epitope/Affinity Tag Positive Control

BC-144 0.2 mL
EUR 195

OVA Conjugated C-Myc Epitope (Myc)

CPX162Ge21 10ug
EUR 120

OVA Conjugated c-Myc Epitope (Myc)

4-CPX162Ge21
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  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Pan-species C-Myc Epitope expressed in: chemical synthesis

OVA Conjugated C-Myc Epitope (Myc)

RPU50047-100ug 100ug
EUR 475.2

OVA Conjugated C-Myc Epitope (Myc)

RPU50047-1mg 1mg
EUR 1872

OVA Conjugated C-Myc Epitope (Myc)

RPU50047-50ug 50ug
EUR 288

Placental Lactogen (Epitope 2) Antibody

GWB-431C2F 0.5 mg Ask for price

Leishmania LPG (Repeat Epitope) Antibody

GWB-A82CDB 0.5 ml Ask for price

Anti- Hemagglutinin (HA) epitope Antibody

GWB-99531B 0.1 mg Ask for price

Anti-VSV-G EPITOPE TAG Antibody

GWB-C86E3F 100 ug Ask for price

Cd18 (Activation Epitope) Antibody (Biotin)

GWB-AB34A9 0.1 mg Ask for price

V5 Epitope Tag Peptide Trifluoroacetate

HY-P0325 10mg
EUR 408

V5 Epitope Tag Peptide Trifluoroacetate

TP1428-10mg 10mg Ask for price
Description: V5 Epitope Tag Peptide Trifluoroacetate

V5 Epitope Tag Peptide Trifluoroacetate

TP1428-1g 1g Ask for price
Description: V5 Epitope Tag Peptide Trifluoroacetate

V5 Epitope Tag Peptide Trifluoroacetate

TP1428-1mg 1mg Ask for price
Description: V5 Epitope Tag Peptide Trifluoroacetate

V5 Epitope Tag Peptide Trifluoroacetate

TP1428-50mg 50mg Ask for price
Description: V5 Epitope Tag Peptide Trifluoroacetate

V5 Epitope Tag Peptide Trifluoroacetate

TP1428-5mg 5mg Ask for price
Description: V5 Epitope Tag Peptide Trifluoroacetate

Anti-hCG alpha 4 epitope antibody

STJ16100837 0.5 mg
EUR 859.2

Anti-Hu CD11b (activation epitope) PE

1P-172-T025 25 tests
EUR 121

Anti-Hu CD11b (activation epitope) PE

1P-172-T100 100 tests
EUR 242

Hepatitis B Ag " e" epitope

GWB-3A3603 0.1 mg Ask for price

IV9 (476 484), HIV 1 RT Epitope Peptide

20-abx266099
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  • 10 mg
  • 25 mg
  • 5 mg

IV9 (476 484), HIV 1 RT Epitope Peptide

abx266099-200tests 200 tests
EUR 262.5

IV9 (476 484), HIV 1 RT Epitope Peptide

abx266099-500tests 500 tests
EUR 375

IHC-Tek Epitope Retrieval Steamer Set

IW-1102 -
EUR 525

Anti-CD3 epsilon (activation epitope) PE

1P-599-C025 0.025 mg
EUR 121

Anti-CD3 epsilon (activation epitope) PE

1P-599-C100 0.1 mg
EUR 242

This approach has long been used to optimize the growth and productivity of bacteria and the production system is being increasingly used to provide insights into human health research. Production of tissue for implantation using a well-optimized MSC requires mass production of cells and understanding of patients and specific phenotypes metabolism situation. This review considers the current knowledge of the metabolism of the MSC and how it can be optimized with the use of current and future genome-scale metabolic modeling based constraints to further this goal.