Extracellular Vesicles Derived From Mesenchymal Stem Cells (MSC) in Regenerative Medicine: Applications in Skin Wound Healing.
The cells secrete extracellular vesicles (EV) which probably has its origins endosomal, or from evaginations of the plasma membrane. The former is usually called exosomes, with sizes ranging from 50 to 100 nm. This EV-containing lipid bilayer membrane protein associated with. Molecules such as nucleic acids (DNA, mRNA, miRNA, lncRNA, etc.) and proteins can be stored inside. EV composition depending on the type of producer cells and physiological conditions.
Through them, the cells and the microenvironment modifying the behavior of neighboring cells. That is done by transferring factors that modulate different metabolic and signaling pathways. Due to their nature, the EV can be applied as a diagnostic and therapeutic tool in medicine. Mesenchymal stromal cells (MSC) have immunomodulatory properties and high regenerative capacity. These features are associated with the activity and EV paracrine secretion. Therefore, the study of exosomes produced by MSC has intensified for use in regenerative medicine cell-free. In this area, the use of EV for the treatment of chronic skin ulcers (CSU) has been proposed.
The injury occurs when the normal healing did not finish well. It is usually due to excessive extension of the inflammatory phase. These ulcers associated with aging and disease, such as diabetes, so that their prevalence increases with one of these latter diseases, especially in developed countries. It has a socio-economic impact is very important. In this review, we show that the application of the MSC-derived EV for the treatment of CSU have a positive effect, including speeding up healing and reduce scar formation. This is because the EV has immunosuppressive properties and immunomodulatory.
Likewise, they have the ability to activate angiogenesis, proliferation, migration, and differentiation of the major cell types involved in the regeneration of the skin. They include endothelial cells, fibroblasts, and keratinocytes. Most studies conducted so far preclinical. Therefore, there is a need to promote a deeper knowledge of the conditions of production, isolation, and mechanisms of action EV. Interestingly, their potential applications in the treatment of CSU opens the door to the design of new therapeutic strategies are highly effective.

comparative advantage infrapatellar fat pad: a source of stem cells for regenerative medicine emerging.
Growing evidence suggests that the infrapatellar fat pad (IPFP) -derived stem cells (IPFSCs) exert a strong proliferative capacity and multilineage differentiation potential. However, some paper summarizes the advantages that IPFP and IPFSCs have in regenerative medicine. In this review, we describe the development and anatomy IPFP by comparing it with the adjacent fibrous tissue, synovium, and more often harvested fat depot, subcutaneous adipose tissue.
In addition, we explore the similarities and differences stem cells from three of these networks in terms IPFSCs, stem cells synovium-derived and stem cell tissue derived subcutaneous adipose in proliferative capacity and tri-lineage differentiation potential, including chondrogenesis, osteogenesis and adipogenesis ,
FitAmp Plasma/Serum DNA Isolation Kit |
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P-1004 | EpiGentek |
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TuMinute PCR Clean-Up Kit |
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P-1005 | EpiGentek |
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DNA Concentrator Kit |
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P-1006 | EpiGentek |
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FitAmp Paraffin Tissue Section DNA Isolation Kit |
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P-1009 | EpiGentek |
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Methylamp One-Step DNA Modification Kit |
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P-1010 | EpiGentek |
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Methylamp Universal Methylated DNA Kit |
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P-1011 | EpiGentek |
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FitAmp Circulating DNA Quantification Kit |
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P-1012 | EpiGentek |
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Methylamp Global DNA Methylation Quantification Ultra Kit |
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P-1014B | EpiGentek |
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Methylamp Methylated DNA Capture (MeDIP) Kit |
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P-1015 | EpiGentek |
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Methylamp Whole Cell Bisulfite Modification Kit |
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P-1016 | EpiGentek |
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FitAmp Urine DNA Isolation Kit |
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P-1017 | EpiGentek |
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FitAmp Blood and Cultured Cell DNA Extraction Kit |
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P-1018 | EpiGentek |
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FitAmp General DNA Quantification Kit |
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P-1020 | EpiGentek |
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SuperSense Methylated DNA Quantification Kit |
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P-1021 | EpiGentek |
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Methylamp MS-qPCR Fast Kit |
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P-1028 | EpiGentek |
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EpiQuik Quantitative PCR Fast Kit |
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P-1029 | EpiGentek |
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MethylFlash Global DNA Hydroxymethylation (5-hmC) ELISA Easy Kit (Colorimetric) |
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P-1032 | EpiGentek |
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MethylFlash Methylated DNA 5-mC Quantification Kit (Colorimetric) |
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P-1034 | EpiGentek |
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MethylFlash Methylated DNA Quantification Kit (Fluorometric) |
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P-1035 | EpiGentek |
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MethylFlash Hydroxymethylated DNA 5-hmC Quantification Kit (Colorimetric) |
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P-1036 | EpiGentek |
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MethylFlash Hydroxymethylated DNA Quantification Kit (Fluorometric) |
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P-1037 | EpiGentek |
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MethylFlash Urine 5-Methylcytosine (5-mC) Quantification Kit (Colorimetric) |
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P-1039 | EpiGentek |
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MethylFlash Urine 5-Methylcytosine (5-mC) Quantification Kit (Fluorometric) |
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P-1040 | EpiGentek |
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MethylFlash 5-Formylcytosine (5-fC) DNA Quantification Kit (Colorimetric) |
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P-1041 | EpiGentek |
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EpiNext DNA Library Preparation Kit (Illumina) |
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P-1051 | EpiGentek |
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EpiQuik MeDIP Ultra Kit |
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P-1052 | EpiGentek |
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EpiNext High-Sensitivity DNA Library Preparation Kit (Illumina) |
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P-1053 | EpiGentek |
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EpiNext Post-Bisulfite DNA Library Preparation Kit (Illumina) |
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P-1055 | EpiGentek |
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EpiNext Bisulfite Sequencing Kit (Illumina) |
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P-1056 | EpiGentek |
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EpiNext DNA Size Selection Kit |
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P-1059 | EpiGentek |
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EpiQuik Circulating Cell-Free DNA Isolation Kit |
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P-1064 | EpiGentek |
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EpiQuik Circulating Cell-Free DNA (ccfDNA) Isolation Easy Kit |
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P-1065 | EpiGentek |
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EpiQuik Methyl-Histone H3K9 ChIP Kit |
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P-2006 | EpiGentek |
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EpiQuik Methyl-Histone H3K4 ChIP Kit |
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P-2007 | EpiGentek |
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EpiQuik Tissue Methyl-Histone H3K9 ChIP Kit |
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P-2008 | EpiGentek |
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EpiQuik Tissue Methyl-Histone H3K4 ChIP Kit |
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P-2009 | EpiGentek |
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EpiQuik Acetyl-Histone H3 ChIP Kit |
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P-2010 | EpiGentek |
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EpiQuik Acetyl-Histone H4 ChIP Kit |
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P-2011 | EpiGentek |
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EpiQuik Tissue Acetyl-Histone H3 ChIP Kit |
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P-2012 | EpiGentek |
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EpiQuik Tissue Acetyl-Histone H4 ChIP Kit |
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P-2013 | EpiGentek |
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EpiQuik Plant ChIP Kit |
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P-2014 | EpiGentek |
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EpiQuik Methyl-Histone H3K27 ChIP Kit |
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P-2015 | EpiGentek |
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EpiQuik Tissue Methyl-Histone H3K27 ChIP Kit |
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P-2016 | EpiGentek |
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EpiQuik Methyl-CpG Binding Domain Protein 2 ChIP Kit |
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P-2017 | EpiGentek |
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EpiQuik Methylated DNA Immunoprecipitation Kit |
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P-2019 | EpiGentek |
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EpiQuik Tissue Methylated DNA Immunoprecipitation Kit |
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P-2020 | EpiGentek |
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ChromaFlash One-Step ChIP Kit |
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P-2025 | EpiGentek |
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ChromaFlash One-Step Magnetic ChIP Kit |
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P-2026 | EpiGentek |
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ChromaFlash High-Sensitivity ChIP Kit |
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P-2027 | EpiGentek |
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EpiNext ChIP-Seq High-Sensitivity Kit (Illumina) |
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P-2030 | EpiGentek |
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Pre-Sure ChIP Antibody Validation Kit |
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P-2031 | EpiGentek |
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EpiQuik DNA Methyltransferase (DNMT) Activity/Inhibition Assay Kit |
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P-3001 | EpiGentek |
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EpiQuik Histone Methyltransferase Activity/Inhibition Assay Kit (H3K4) |
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P-3002 | EpiGentek |
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EpiQuik Histone Methyltransferase Activity/Inhibition Assay Kit (H3K9) |
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P-3003 | EpiGentek |
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EpiQuik DNA Methyltransferase (DNMT) Activity/Inhibition Assay Kit (Fluorometric) |
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P-3004 | EpiGentek |
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EpiQuik Histone Methyltransferase Activity/Inhibition Assay Kit (H3K27) |
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P-3005 | EpiGentek |
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EpiQuik DNMT1 Activity/Inhibitor Screening Assay Core Kit |
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P-3006A | EpiGentek |
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EpiQuik DNMT3B Activity/Inhibitor Screening Assay Core Kit |
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P-3007A | EpiGentek |
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EpiQuik DNA Demethylase Activity/Inhibition Assay Ultra Kit |
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P-3008 | EpiGentek |
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EpiQuik DNMT Activity/Inhibition Assay Ultra Kit (Colorimetric) |
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P-3009 | EpiGentek |
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EpiQuik DNMT Activity/Inhibition Assay Ultra Kit (Fluorometric) |
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P-3010 | EpiGentek |
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EpiQuik Dnmt1 Assay Kit |
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P-3011 | EpiGentek |
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EpiQuik Dnmt3A Assay Kit |
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P-3012 | EpiGentek |
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EpiQuik Dnmt3B Assay Kit |
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P-3013 | EpiGentek |
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EpiQuik In Situ Histone H3K27 Tri-Methylation Assay Kit |
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P-3014T | EpiGentek |
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EpiQuik In Situ Histone H3K4 Methylation Assay Kit |
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P-3015 | EpiGentek |
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EpiQuik In Situ Histone H3K9 Methylation Assay Kit |
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P-3016 | EpiGentek |
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EpiQuik Global Histone H3K4 Methylation Assay Kit |
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P-3017 | EpiGentek |
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EpiQuik Global Histone H3K9 Methylation Assay Kit |
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P-3018 | EpiGentek |
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EpiQuik DNA Demethylase Activity/Inhibition Assay Kit |
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P-3019 | EpiGentek |
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EpiQuik Global Histone H3K27 Methylation Assay Kit |
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P-3020 | EpiGentek |
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EpiQuik Global Di-Methyl Histone H3K4 Quantification Kit (Colorimetric) |
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P-3022 | EpiGentek |
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EpiQuik Global Di-Methyl Histone H3K4 Quantification Kit (Fluorometric) |
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P-3023 | EpiGentek |
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EpiQuik Global Mono-Methyl Histone H3K4 Quantification Kit (Colorimetric) |
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P-3024 | EpiGentek |
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EpiQuik Global Mono-Methyl Histone H3K4 Quantification Kit (Fluorometric) |
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P-3025 | EpiGentek |
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EpiQuik Global Tri-Methyl Histone H3K4 Quantification Kit (Colorimetric) |
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P-3026 | EpiGentek |
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EpiQuik Global Tri-Methyl Histone H3K4 Quantification Kit (Fluorometric) |
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P-3027 | EpiGentek |
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EpiQuik Global Mono-Methyl Histone H3K9 Quantification Kit (Colorimetric) |
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P-3030 | EpiGentek |
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EpiQuik Global Mono-Methyl Histone H3K9 Quantification Kit (Fluorometric) |
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P-3031 | EpiGentek |
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EpiQuik Global Di-Methyl Histone H3K9 Quantification Kit (Colorimetric) |
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P-3032 | EpiGentek |
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EpiQuik Global Di-Methyl Histone H3K9 Quantification Kit (Fluorometric) |
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P-3033 | EpiGentek |
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EpiQuik Global Tri-Methyl Histone H3K9 Quantification Kit (Colorimetric) |
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P-3034 | EpiGentek |
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EpiQuik Global Tri-Methyl Histone H3K9 Quantification Kit (Fluorometric) |
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P-3035 | EpiGentek |
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EpiQuik Global Mono-Methyl Histone H3K27 Quantification Kit (Colorimetric) |
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P-3038 | EpiGentek |
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EpiQuik Global Mono-Methyl Histone H3K27 Quantification Kit (Fluorometric) |
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P-3039 | EpiGentek |
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EpiQuik Global Di-Methyl Histone H3K27 Quantification Kit (Colorimetric) |
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P-3040 | EpiGentek |
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EpiQuik Global Di-Methyl Histone H3K27 Quantification Kit (Fluorometric) |
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P-3041 | EpiGentek |
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EpiQuik Global Tri-Methyl Histone H3K27 Quantification Kit (Colorimetric) |
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P-3042 | EpiGentek |
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EpiQuik Global Tri-Methyl Histone H3K27 Quantification Kit (Fluorometric) |
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P-3043 | EpiGentek |
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EpiQuik Global Mono-Methyl Histone H3K36 Quantification Kit (Colorimetric) |
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P-3046 | EpiGentek |
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EpiQuik Global Mono-Methyl Histone H3K36 Quantification Kit (Fluorometric) |
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P-3047 | EpiGentek |
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EpiQuik Global Di-Methyl Histone H3K36 Quantification Kit (Colorimetric) |
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P-3048 | EpiGentek |
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EpiQuik Global Di-Methyl Histone H3K36 Quantification Kit (Fluorometric) |
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P-3049 | EpiGentek |
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MethylFlash Global DNA Methylation (5-mC) ELISA Easy Kit (Colorimetric) |
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P-1030 | EpiGentek |
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EpiQuik Global Tri-Methyl Histone H3K36 Quantification Kit (Colorimetric) |
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P-3050 | EpiGentek |
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EpiQuik Global Tri-Methyl Histone H3K36 Quantification Kit (Fluorometric) |
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P-3051 | EpiGentek |
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EpiQuik Global Mono-Methyl Histone H3K79 Quantification Kit (Colorimetric) |
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P-3054 | EpiGentek |
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EpiQuik Global Mono-Methyl Histone H3K79 Quantification Kit (Fluorometric) |
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P-3055 | EpiGentek |
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EpiQuik Global Di-Methyl Histone H3K79 Quantification Kit (Colorimetric) |
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P-3056 | EpiGentek |
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EpiQuik Global Di-Methyl Histone H3K79 Quantification Kit (Fluorometric) |
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P-3057 | EpiGentek |
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EpiQuik Global Tri-Methyl Histone H3K79 Quantification Kit (Colorimetric) |
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P-3058 | EpiGentek |
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EpiQuik Global Tri-Methyl Histone H3K79 Quantification Kit (Fluorometric) |
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P-3059 | EpiGentek |
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EpiQuik Total Histone H3 Quantification Kit (Colorimetric) |
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P-3062 | EpiGentek |
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EpiQuik Total Histone H3 Quantification Kit (Fluorometric) |
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P-3063 | EpiGentek |
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EpiQuik Global Mono-Methyl Histone H4K20 Quantification Kit (Colorimetric) |
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P-3064 | EpiGentek |
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EpiQuik Global Mono-Methyl Histone H4K20 Quantification Kit (Fluorometric) |
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P-3065 | EpiGentek |
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EpiQuik Global Di-Methyl Histone H4K20 Quantification Kit (Colorimetric) |
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P-3066 | EpiGentek |
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EpiQuik Global Di-Methyl Histone H4K20 Quantification Kit (Fluorometric) |
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P-3067 | EpiGentek |
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EpiQuik Global Tri-Methyl Histone H4K20 Quantification Kit (Colorimetric) |
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P-3068 | EpiGentek |
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EpiQuik Global Tri-Methyl Histone H4K20 Quantification Kit (Fluorometric) |
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P-3069 | EpiGentek |
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EpiQuik Total Histone H4 Quantification Kit (Colorimetric) |
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P-3072 | EpiGentek |
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EpiQuik Total Histone H4 Quantification Kit (Fluorometric) |
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P-3073 | EpiGentek |
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EpiQuik Histone Demethylase (H3K4 Specific) Activity/Inhibition Assay Kit |
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P-3074 | EpiGentek |
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EpiQuik Histone Demethylase LSD1 Inhibitor Screening Assay Core Kit |
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P-3075A | EpiGentek |
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Epigenase LSD1 Demethylase Activity/Inhibition Assay Kit (Colorimetric) |
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P-3078 | EpiGentek |
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Epigenase LSD1 Demethylase Activity/Inhibition Assay Kit (Fluorometric) |
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P-3079 | EpiGentek |
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Epigenase JMJD2 Demethylase Activity/Inhibition Assay Kit (Colorimetric) |
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P-3080 | EpiGentek |
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Epigenase JMJD2 Demethylase Activity/Inhibition Assay Kit (Fluorometric) |
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P-3081 | EpiGentek |
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Epigenase JARID Demethylase Activity/Inhibition Assay Kit (Colorimetric) |
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P-3082 | EpiGentek |
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Epigenase JARID Demethylase Activity/Inhibition Assay Kit (Fluorometric) |
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P-3083 | EpiGentek |
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Epigenase JMJD3/UTX Demethylase Activity/Inhibition Assay Kit (Colorimetric) |
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P-3084 | EpiGentek |
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Epigenase JMJD3/UTX Demethylase Activity/Inhibition Assay Kit (Fluorometric) |
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P-3085 | EpiGentek |
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Epigenase 5mC-Hydroxylase TET Activity/Inhibition Assay Kit (Colorimetric) |
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P-3086 | EpiGentek |
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Epigenase 5mC-Hydroxylase TET Activity/Inhibition Assay Kit (Fluorometric) |
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P-3087 | EpiGentek |
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Epigenase PRMT Methyltransferase (Type II-Specific) Activity/Inhibition Assay Kit (Colorimetric) |
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P-3088 | EpiGentek |
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EpiQuik Global Di-Methyl Histone H4R3 Quantification Kit (Colorimetric) |
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P-3090 | EpiGentek |
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EpiQuik Circulating Total Histone H3 Quantification Kit (Colorimetric) |
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P-3091 | EpiGentek |
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Epigenase Thymine DNA Glycosylase (TDG) Activity/Inhibition Assay Kit (Colorimetric) |
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P-3094 | EpiGentek |
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EpiQuik Histone H3 Citrullination ELISA Kit (Colorimetric) |
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P-3095 | EpiGentek |
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EpiQuik Global Di-Methyl Histone H3R8 Quantification Kit (Colorimetric) |
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P-3096 | EpiGentek |
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EpiQuik Circulating Histone H3 Citrullination ELISA Kit (Colorimetric) |
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P-3097 | EpiGentek |
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EpiQuik Circulating Monomethyl Histone H3K4 ELISA Kit (Colorimetric) |
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P-3108 | EpiGentek |
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EpiQuik Circulating Dimethyl Histone H3K4 ELISA Kit (Colorimetric) |
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P-3110 | EpiGentek |
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EpiQuik Circulating Trimethyl Histone H3K4 ELISA Kit (Colorimetric) |
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P-3112 | EpiGentek |
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EpiQuik Circulating Monomethyl Histone H3K9 ELISA Kit (Colorimetric) |
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P-3114 | EpiGentek |
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EpiQuik Circulating Dimethyl Histone H3K9 ELISA Kit (Colorimetric) |
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P-3116 | EpiGentek |
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EpiQuik Circulating Trimethyl Histone H3K9 ELISA Kit (Colorimetric) |
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P-3118 | EpiGentek |
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EpiQuik Circulating Monomethyl Histone H3K27 ELISA Kit (Colorimetric) |
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P-3120 | EpiGentek |
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EpiQuik Circulating Dimethyl Histone H3K27 ELISA Kit (Colorimetric) |
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P-3122 | EpiGentek |
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EpiQuik Circulating Trimethyl Histone H3K27 ELISA Kit (Colorimetric) |
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P-3124 | EpiGentek |
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EpiQuik Circulating Monomethyl Histone H3K36 ELISA Kit (Colorimetric) |
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P-3126 | EpiGentek |
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EpiQuik Circulating Dimethyl Histone H3K36 ELISA Kit (Colorimetric) |
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P-3128 | EpiGentek |
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Finally, we highlight the advantages of IPFSCs in regenerative medicine, such as abundant accessibility and ability to resist inflammation and aging, two hurdles for cell-based tissue regeneration. Given the comparative advantage of IPFSCs, which IPFP can serve as a source of stem cells for regenerative medicine is very good, especially for the regeneration of cartilage.